SCHEMBL2145810

SCHEMBL2145810

Fc1cnc(C(F)(F)F)c(F)c1F

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KDM5B Q9UGL1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23818326 0.78 — —
SCHEMBL23099873 0.70 CCR1 (0.35) KDM5B
SCHEMBL20639130 0.69 KDM4E (0.50) —
SCHEMBL586361 0.69 VRK1 (0.35) —
SCHEMBL20638849 0.68 GRIN2B (0.33) —
SCHEMBL23976834 0.67 MBOAT4 (0.32) —
SCHEMBL23976836 0.67 TRPV4 (0.32) —
SCHEMBL23148021 0.67 — —
SCHEMBL24843484 0.67 UHRF1 (0.33) —
SCHEMBL23832855 0.67 ENPP3 (0.37) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4745193-A Process for the preparation of fluoromethylpyridines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-05-17 — — US claimed
EP-0063872-B1 PROCESS FOR THE PREPARATION OF FLUOROMETHYL PYRIDINES AND CERTAIN NOVEL PRODUCTS OBTAINED THEREFROM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-07-17 — — EP claimed
EP-0063872-A1 Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-03 — — EP claimed
US-8921382-B2 Thiazolo[5,4-d] pyrimidines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-12-30 — — US disclosed
US-8921382-B2 Thiazolo[5,4-d] pyrimidines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-12-30 — — US disclosed
US-8921382-B2 Thiazolo[5,4-d] pyrimidines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-12-30 — — US disclosed
EP-2521452-B1 THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2014-12-24 — — EP disclosed
EP-2521452-B1 THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2014-12-24 — — EP disclosed
US-8895568-B2 Compositions comprising substituted pteridines as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-11-25 — — US disclosed
US-8895568-B2 Compositions comprising substituted pteridines as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-11-25 — — US disclosed
US-20130252960-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2013-09-26 — — US disclosed
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC 2011-07-07 — — US disclosed
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC 2011-07-07 — — US disclosed
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC 2011-07-07 — — US disclosed
US-20110054173-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2011-03-03 — — US disclosed
US-20110054173-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2011-03-03 — — US disclosed
US-4745193-A Process for the preparation of fluoromethylpyridines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-05-17 — — US disclosed
EP-0063872-B1 PROCESS FOR THE PREPARATION OF FLUOROMETHYL PYRIDINES AND CERTAIN NOVEL PRODUCTS OBTAINED THEREFROM IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-07-17 — — EP disclosed
EP-0063872-A1 Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-03 — — EP disclosed
EP-0063872-A1 Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130252960-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS CBR3, CBR1, AKR1C4 KDM5B 175/4885
US-20110166164-A1 THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS DPYD, TYMS, TYMP KDM5B 1888/4885
US-20110054173-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS PIR, PFAS, PNPO KDM5B 1336/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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