Nimbolide

Nimbolide

SCHEMBL2146198

COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](c4ccoc4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RNF114 Q9Y508 3/20 1.00
HSP90AA1 P07900 1/20 0.54
BRD4 O60885 1/20 0.46
CYP3A4 P08684 13/20 0.38
USP2 O75604 6/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 1/20 0.38
TDP1 Q9NUW8 1/20 0.34
HPGD P15428 1/20 0.33
SLCO1B3 Q9NPD5 1/20 0.33
SLCO1B1 Q9Y6L6 1/20 0.33
MAPK1 P28482 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nimbolide SCHEMBL26312156 1.00 RNF114 (1.00) RNF114HSP90AA1BRD4CYP3A4USP2
Nimbolide SCHEMBL23483973 1.00 RNF114 (1.00) RNF114HSP90AA1BRD4CYP3A4USP2
Nimbolide SCHEMBL26690496 1.00 RNF114 (1.00) RNF114HSP90AA1BRD4CYP3A4USP2
Nimbolide SCHEMBL21163877 1.00 RNF114 (1.00) RNF114HSP90AA1BRD4CYP3A4USP2
SCHEMBL26698833 0.93 RNF114 (0.86) RNF114HSP90AA1BRD4CYP3A4USP2
SCHEMBL24076795 0.92 RNF114 (0.86) RNF114HSP90AA1BRD4CYP3A4USP2
SCHEMBL24625130 0.90 RNF114 (0.82) RNF114HSP90AA1BRD4CYP3A4
SCHEMBL24076672 0.88 RNF114 (0.78) RNF114HSP90AA1BRD4
SCHEMBL24625481 0.88 RNF114 (0.78) RNF114HSP90AA1BRD4
SCHEMBL24076520 0.86 RNF114 (0.76) RNF114HSP90AA1BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 327 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260102453-A1 NEEM TREE LEAVES EXTRACT VORDERWUELBECKE LAURENZ (DE) 2026-04-16 US claimed
US-20260048131-A1 BIFUNCTIONAL COMPOUNDS AND USES THEREOF RISEN SUZHOU PHARMA TECH CO LTD (CN) 2026-02-19 US claimed
EP-4630422-A1 BIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL USES THEREOF Risen (Suzhou) Pharma Tech Co., Ltd. (CN) 2025-10-15 EP claimed
EP-4590316-A1 NEEM TREE LEAVES EXTRACT Vorderwülbecke, Laurenz (DE) 2025-07-30 EP claimed
EP-4587446-A1 BIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL USES THEREOF Risen (Suzhou) Pharma Tech Co., Ltd. (CN) 2025-07-23 EP claimed
WO-2025063888-A1 SURVIVIN-TARGETED COMPOUNDS KANCURE PTE. LTD. (SG) 2025-03-27 WO claimed
US-20250090490-A1 Compositions of Azadirachta Indica and Methods of Treating Cancer UNIV TEXAS (US) 2025-03-20 US claimed
WO-2025007920-A1 COMBINED DRUG FOR DEGRADING ESTROGEN RECEPTOR AND USE THEREOF 海创药业股份有限公司 2025-01-09 WO claimed
CN-119258223-A Combined medicine for degrading estrogen receptor and application thereof 海创药业股份有限公司 2025-01-07 CN claimed
US-20240336622-A1 NIMBOLIDE ANALOGS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-10-10 US claimed
US-20200069636-A1 PROCESS FOR PREPARATION OF CO2 EXTRACT OF AZADIRACHTA INDICA AND HERBAL COMPOSITIONS THEREOF FOR TREATMENT OF CANCERS NISARGA BIOTECH PRIVATE LIMITED (IN) 2020-03-05 US claimed
WO-2020047405-A1 COMPOSITIONS OF AZADIRACHTA INDICA AND METHODS OF TREATING CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-03-05 WO claimed
US-20190211027-A1 NIMBOLIDE ANALOGS AS ANTI-CANCER AGENTS AND PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2019-07-11 US claimed
US-20180255787-A1 PEST CONTROL FORMULATIONS AND METHODS OF MAKING AND USING SAME 0903608 B.C. LTD. (CA) 2018-09-13 US claimed
WO-2016089977-A1 SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH CELGENE CORPORATION (US) 2016-06-09 WO claimed
WO-2015035199-A1 NEEM COMPOSITIONS USED FOR THE TREATMENT OF CANCER MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2015-03-12 WO claimed
US-20140242199-A1 PEST CONTROL FORMULATIONS AND METHODS OF MAKING AND USING SAME 0903608 B.C. LTD. (CA) 2014-08-28 US claimed
EP-2763541-A1 PEST CONTROL FORMULATIONS AND METHODS OF MAKING AND USING SAME 0903608 B.C. Ltd. (CA) 2014-08-13 EP claimed
CN-103974621-A Pest control formulations and methods of making and using the same 0903608 B C LTD 2014-08-06 CN claimed
WO-2013050967-A1 PEST CONTROL FORMULATIONS AND METHODS OF MAKING AND USING SAME 0903608 B.C. LTD. (CA) 2013-04-11 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180255787-A1 PEST CONTROL FORMULATIONS AND METHODS OF MAKING AND USING SAME ACHE, DDT, SGMS2 RNF114 4225/4885HSP90AA1 2076/4885BRD4 4165/4885
US-20260048131-A1 BIFUNCTIONAL COMPOUNDS AND USES THEREOF KRAS, MDM2, VHL RNF114 84/4885HSP90AA1 2743/4885BRD4 1314/4885
US-20200069636-A1 PROCESS FOR PREPARATION OF CO2 EXTRACT OF AZADIRACHTA INDICA AND HERBAL COMPOSITIONS THEREOF FOR TREATMENT OF CANCERS SCO2, SI, CYP1A2 RNF114 2800/4885HSP90AA1 2721/4885BRD4 3493/4885
US-20190211027-A1 NIMBOLIDE ANALOGS AS ANTI-CANCER AGENTS AND PREPARATION THEREOF CCND1, CBR3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 RNF114 1219/4885HSP90AA1 2582/4885BRD4 1642/4885
US-20240336622-A1 NIMBOLIDE ANALOGS AND METHODS OF USE THEREOF PARP1, PARP11, PARP12 RNF114 2576/4885HSP90AA1 2674/4885BRD4 196/4885
US-20260102453-A1 NEEM TREE LEAVES EXTRACT NNT, NNMT, NPM1 RNF114 3264/4885HSP90AA1 3770/4885BRD4 548/4885
US-20140242199-A1 PEST CONTROL FORMULATIONS AND METHODS OF MAKING AND USING SAME ACHE, DDT, SGMS2 RNF114 4225/4885HSP90AA1 2076/4885BRD4 4165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.