Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 6/20 | 0.56 |
| ▸ | GABRD | O14764 | 6/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.56 |
| ▸ | GABRE | P78334 | 6/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.56 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.56 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.56 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.56 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30615505 | 0.83 | AURKA (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30615630 | 0.83 | AURKA (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21464439 | 0.81 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30615440 | 0.81 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30615474 | 0.81 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21463351 | 0.81 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24405829 | 0.75 | PDE10A (0.40) | MEN1KMT2AMAPTMAP4K1 | |
| SCHEMBL21463990 | 0.75 | AURKA (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21463917 | 0.74 | DAO (0.47) | — | |
| SCHEMBL30615331 | 0.74 | DAO (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11802120-B2 | Fused cyclic urea derivatives as CRHR2 antagonist | RAQUALIA PHARMA INC. (JP) | 2023-10-31 | — | — | US | disclosed |
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |
| US-20210078975-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2021-03-18 | — | — | US | disclosed |
| EP-3774739-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RaQualia Pharma Inc. (JP) | 2021-02-17 | — | — | EP | disclosed |
| CN-111868037-A | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2020-10-30 | — | — | CN | disclosed |
| WO-2019198692-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078975-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | CRHR2, CRHR1, CRH | GABRP 731/4885GABRD 469/4885GABRA1 640/4885 |
| US-11802120-B2 | Fused cyclic urea derivatives as CRHR2 antagonist | CRHR2, CRHR1, CRH | GABRP 731/4885GABRD 469/4885GABRA1 640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.