Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11360661 | 0.90 | HRH3 (0.54) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL21633733 | 0.88 | HRH3 (0.54) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL8778552 | 0.86 | HRH3 (0.56) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL22248702 | 0.85 | HRH3 (0.62) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL20234326 | 0.85 | HRH3 (0.61) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL3141888 | 0.83 | SMN1; SMN2 (0.55) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL22248703 | 0.83 | HRH3 (0.65) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL18222955 | 0.82 | KMT2A (0.50) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL1535645 | 0.82 | KDM4E (0.53) | KDM4ESMN1; SMN2HRH3APPRAB9A | |
| SCHEMBL9593021 | 0.81 | HRH3 (0.57) | KDM4ESMN1; SMN2HRH3APPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903090-B2 | Such as 10-(2-ethoxyphenyl)-1,2,3,4,5,6-hexahydroazepino(4,5-b)indole; for treatment of anxiety, depression, schizophrenia, epilepsy, migraine, Alzheimers disease, sleep disorders, obesity, stress related diseases, and/or drug withdrawal | PFIZER (US) | 2005-06-07 | — | — | US | claimed |
| US-6828314-B2 | Modulation of the activity of serotonin receptors (5-HT) to treat diseases such as anxiety, depression or obesity | PFIZER | 2004-12-07 | — | — | US | claimed |
| US-20030225058-A1 | Substituted azepino[4,5b]indoline derivatives | PHARMACIA & UPJOHN COMPANY | 2003-12-04 | — | — | US | claimed |
| US-20030220321-A1 | Substituted azepino[4,5b]indole derivatives | PHARMACIA & UPJOHN COMPANY | 2003-11-27 | — | — | US | claimed |
| EP-1319005-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | claimed |
| EP-1319004-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | claimed |
| US-20020107278-A1 | Substituted azepino[4,5b]indole derivatives | PHARMACIA & UPJOHN COMPANY | 2002-08-08 | — | — | US | claimed |
| US-20020077318-A1 | Substituted azepino[4,5b] indoline derivatives | PHARMACIA & UPJOHN COMPANY | 2002-06-20 | — | — | US | claimed |
| WO-2002024701-A2 | SUBSTITUTED AZEPINO[4,5B)INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | claimed |
| WO-2002024700-A2 | SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | claimed |
| EP-0548285-B1 | FUNGICIDAL 3,3-BIS[ALKYLTHIO]-2-PYRIDYLACRYLIC ACID DERIVATIVES | UNIROYAL CHEM CO INC (US) | 1995-10-18 | — | — | EP | claimed |
| EP-0548285-A1 | FUNGICIDAL 3,3-BISTHIOALKYL-2-PYRIDYLACRYLIC ACID DERIVATIVES. | UNIROYAL CHEM CO INC (US) | 1993-06-30 | — | — | EP | claimed |
| WO-1992005155-A1 | FUNGICIDAL 3,3-BISTHIOALKYL-2-PYRIDYLACRYLIC ACID DERIVATIVES | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1992-04-02 | — | — | WO | claimed |
| US-5061716-A | PHYTOPATHOGENS | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1991-10-29 | — | — | US | claimed |
| US-8088878-B2 | Hydrosilylation reactions activated through radiation | WACKER CHEMIE AG (DE) | 2012-01-03 | — | — | US | disclosed |
| EP-2238145-B1 | HYDROSILYLATION REACTIONS ACTIVATED THROUGH RADIATION | WACKER CHEMIE AG (DE) | 2011-08-24 | — | — | EP | disclosed |
| US-7842771-B2 | Self-adhesive addition-crosslinking silicone compositions | WACKER CHEMIE AG (DE) | 2010-11-30 | — | — | US | disclosed |
| US-5061716-A | PHYTOPATHOGENS | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1991-10-29 | — | — | US | disclosed |
| EP-0227640-A1 | Polyolefins stabilised by bis-(polyalkylpiperidinyl-amino)-1,3,5-triazines | CIBA-GEIGY AG (CH) | 1987-07-01 | — | — | EP | disclosed |
| EP-0107615-A1 | Polyolefins stabilized by bis or tris (polyalkylpiperidinyl-amino) 1,3,5-triazines | CIBA-GEIGY AG (CH) | 1984-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107278-A1 | Substituted azepino[4,5b]indole derivatives | HTR5A, HTR1A, HTR1E | KDM4E 1122/4885SMN1; SMN2 1296/4885HRH3 303/4885 |
| US-20030225058-A1 | Substituted azepino[4,5b]indoline derivatives | HTR5A, HTR1A, HTR4 | KDM4E 927/4885SMN1; SMN2 1106/4885HRH3 260/4885 |
| US-20030220321-A1 | Substituted azepino[4,5b]indole derivatives | HTR5A, HTR1A, HTR1E | KDM4E 1122/4885SMN1; SMN2 1296/4885HRH3 303/4885 |
| US-20020077318-A1 | Substituted azepino[4,5b] indoline derivatives | HTR5A, HTR1A, HTR4 | KDM4E 927/4885SMN1; SMN2 1106/4885HRH3 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.