Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428675 | 0.82 | HTR1A (0.54) | MAP4K4MEN1 | |
| SCHEMBL695032 | 0.80 | LMNA (0.53) | METAP2DYRK1BMEN1AURKANPC1 | |
| SCHEMBL28134960 | 0.74 | CYP2A6 (0.50) | METAP2MEN1PSIP1AXLMKNK1 | |
| SCHEMBL22347150 | 0.71 | MAP4K4 (0.49) | METAP2ENPP2MAP4K4MEN1PSIP1 | |
| SCHEMBL8266373 | 0.70 | FGFR1 (0.70) | METAP2MAP4K4DYRK1BMEN1AXL | |
| SCHEMBL30500254 | 0.70 | MAOA (0.83) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL29403794 | 0.70 | MAOA (0.83) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL251095 | 0.70 | MAOA (0.83) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL28093874 | 0.69 | METAP2 (0.68) | METAP2ENPP2MAP4K4AXLPIK3CD | |
| SCHEMBL980068 | 0.68 | CHEK1 (0.59) | METAP2ENPP2MAP4K4MEN1PSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019196937-A1 | SELECTIVE JAK2 INHIBITOR AND APPLICATION THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |