Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928666 | 0.85 | GAA (0.67) | GAAKDM4EMAPTGFERLMNA | |
| SCHEMBL29840068 | 0.85 | GAA (0.67) | GAAKDM4EMAPTGFERLMNA | |
| SCHEMBL2092372 | 0.82 | SIGMAR1 (0.47) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2092377 | 0.82 | GRIK1 (0.50) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2315522 | 0.80 | L3MBTL1 (0.59) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8332997 | 0.80 | SIGMAR1 (0.55) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13186811 | 0.80 | MEN1 (0.62) | TP53MAPK1ALDH1A1POLBCYP1A2 | |
| SCHEMBL74521 | 0.80 | ALDH1A1 (0.61) | SIGMAR1KDM4EMAPK1HTTALDH1A1 | |
| SCHEMBL11430910 | 0.79 | POLB (0.47) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6288808 | 0.78 | HDAC3 (0.63) | GRIK1MAPTTP53MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103221388-A | Novel sulfonamide compounds for inhibition of metastatic tumor growth | METASIGNAL THERAPEUTICS INC | 2013-07-24 | — | — | CN | claimed |
| CN-110878035-B | Method for preparing symmetrical urea compound | 中国科学院化学研究所 | 2021-01-05 | — | — | CN | disclosed |
| EP-2948430-B1 | PHENYLACETYLENES | UNIV OREGON (US) | 2020-05-20 | — | — | EP | disclosed |
| CN-110878035-A | Method for preparing symmetrical urea compound | 中国科学院化学研究所 | 2020-03-13 | — | — | CN | disclosed |
| US-9964531-B2 | Phenylacetylenes | UNIVERSITY OF OREGON (US) | 2018-05-08 | — | — | US | disclosed |
| US-9964531-B2 | Phenylacetylenes | UNIVERSITY OF OREGON (US) | 2018-05-08 | — | — | US | disclosed |
| CN-103221388-B | For the novel sulfonamide compounds suppressing metastatic tumo(u)r to grow | 维理生物技术公司 | 2016-09-28 | — | — | CN | disclosed |
| US-9353093-B2 | Indole-1-carboxamides as kinase inhibitors | ALLERGAN, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-9353093-B2 | Indole-1-carboxamides as kinase inhibitors | ALLERGAN, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-9353093-B2 | Indole-1-carboxamides as kinase inhibitors | ALLERGAN, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20070049558-A1 | New Spirotricyclic Derivatives and Their Use as Phosphodiesterase-7 Inhibitors | PFIZER INC. | 2007-03-01 | — | — | US | disclosed |
| CN-1914173-A | Quinolines useful in treating cardiovascular disease | WYETH CORP (US) | 2007-02-14 | — | — | CN | disclosed |
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | ARENA PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| US-20040214843-A1 | Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | PFIZER INC | 2004-10-28 | — | — | US | disclosed |
| CN-1498212-A | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | ��������ʲ��������ι�˾ | 2004-05-19 | — | — | CN | disclosed |
| EP-1373224-A1 | NEW SPIROTRICYCLIC DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | Warner-Lambert Company LLC (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20020198198-A1 | Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT COMPANY LLC | 2002-12-26 | — | — | US | disclosed |
| WO-2002076953-A1 | NEW SPIROTRICYCLIC DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-10-03 | — | — | WO | disclosed |
| WO-2002074754-A1 | NEW SPIROTRICYCLIC DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE-7 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198198-A1 | Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | PDE3A, PDE12, PDE5A | SIGMAR1 3442/4885GRIN2D 4181/4885GRIN3B 4450/4885 |
| US-20040214843-A1 | Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | PDE3A, PDE12, PDE5A | SIGMAR1 3442/4885GRIN2D 4181/4885GRIN3B 4450/4885 |
| US-20070010671-A1 | Novel quinazoline derivatives and methods of treatment related to the use thereof | MCHR1, GPR119, MCHR2 | SIGMAR1 125/4885GRIN2D 304/4885GRIN3B 234/4885 |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | SIGMAR1 283/4885GRIN2D 265/4885GRIN3B 223/4885 |
| US-20070049558-A1 | New Spirotricyclic Derivatives and Their Use as Phosphodiesterase-7 Inhibitors | PDE3A, PDE4A, PDE5A | SIGMAR1 3121/4885GRIN2D 4289/4885GRIN3B 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.