Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21486187 | 0.81 | TRPM8 (0.37) | TRPM8ALDH1A1DHODHGPBAR1AR | |
| SCHEMBL2017942 | 0.80 | FBP1 (0.40) | FBP1TRPM8ALDH1A1MEN1KMT2A | |
| SCHEMBL9929067 | 0.70 | PIK3CD (0.37) | FBP1ALDH1A1TDP1 | |
| SCHEMBL9953176 | 0.69 | LMNA (0.39) | FBP1MEN1KMT2AMAPT | |
| SCHEMBL2017946 | 0.69 | LMNA (0.37) | FBP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12632710 | 0.67 | FBP1 (0.39) | FBP1TRPM8ALDH1A1MEN1KMT2A | |
| SCHEMBL15621481 | 0.67 | TRPM8 (0.40) | TRPM8ALDH1A1KMT2ADHODHGPBAR1 | |
| SCHEMBL2015194 | 0.67 | KDM4E (0.40) | ALDH1A1MEN1KMT2AMAPTPKM | |
| SCHEMBL25620931 | 0.67 | HTT (0.46) | TRPM8MAPTHTTSMN1; SMN2 | |
| SCHEMBL2012584 | 0.67 | GRIN2D (0.37) | ALDH1A1MEN1KMT2ADHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-B1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE HOLDINGS CORP (US) | 2019-10-23 | — | — | EP | disclosed |