SCHEMBL21490293

SCHEMBL21490293

C=CC(=O)OCc1cc(F)c(F)cc1F

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 4/20 0.46
MMP12 P39900 3/20 0.46
MMP1 P03956 2/20 0.46
MMP9 P14780 2/20 0.46
TSHR P16473 6/20 0.38
ALDH1A1 P00352 4/20 0.38
TP53 P04637 3/20 0.38
HIF1A Q16665 3/20 0.38
CYP3A4 P08684 2/20 0.38
HSD17B10 Q99714 1/20 0.38
THRB P10828 3/20 0.37
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HPGD P15428 1/20 0.35
DPP4 P27487 2/20 0.33
HCAR2 Q8TDS4 1/20 0.33
HDAC1 Q13547 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
USP28 Q96RU2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13773048 0.83 TSHR (0.36) MMP2MMP12MMP1MMP9TSHR
SCHEMBL21517449 0.78 RIPK1 (0.43) MMP2MMP12MMP1MMP9TSHR
SCHEMBL43822 0.78 MMP2 (0.43) MMP2MMP12MMP1MMP9DPP4
SCHEMBL528065 0.77 ALDH1A1 (0.50) MMP2MMP12MMP1MMP9TSHR
SCHEMBL38664955 0.76 FFAR1 (0.41) THRB
SCHEMBL44032 0.76 MMP2 (0.49) MMP2MMP12MMP1MMP9ALDH1A1
SCHEMBL4606745 0.75 F13A1 (0.46) MMP2MMP12MMP1MMP9TSHR
SCHEMBL16977650 0.75 THRB (0.41) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL20925129 0.74 TSHR (0.36) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL18468423 0.74 THRB (0.40) TSHRALDH1A1TP53HIF1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4484407-A2 (METH)ACRYLATE COMPOUND, ADDITIVE FOR OPTICAL RESIN, OPTICAL ELEMENT, AND OPTICAL DEVICE NIKON CORPORATION (JP) 2025-01-01 EP disclosed
CN-116082563-B (Meth) acrylate compound, optical resin additive, optical element, and optical device 株式会社 尼康 2024-09-20 CN disclosed
CN-118359760-A Optical resin, optical element, and optical device 株式会社 尼康 2024-07-19 CN disclosed
CN-116082563-A (meth) acrylate compound, optical resin additive, optical element, and optical device 株式会社 尼康 2023-05-09 CN disclosed
US-11142636-B2 (Meth)acrylate compound, additive for optical resin, optical element, and optical device NIKON CORPORATION (JP) 2021-10-12 US disclosed
US-20190322857-A1 (METH)ACRYLATE COMPOUND, ADDITIVE FOR OPTICAL RESIN, OPTICAL ELEMENT, AND OPTICAL DEVICE NIKON CORPORATION (JP) 2019-10-24 US disclosed