SCHEMBL21493472

SCHEMBL21493472

CC1(C)OB(/C=C/c2cnc3c(c2)NC(=O)CO3)OC1(C)C

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 4/20 0.39
PARP1 P09874 1/20 0.33
MGLL Q99685 1/20 0.33
MMP12 P39900 1/20 0.32
AKR1C3 P42330 1/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
TRPV1 Q8NER1 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2796664 0.76 NR3C2 (0.41) NR3C2PARP1MGLLMMP12
SCHEMBL391545 0.76 NR3C2 (0.42) NR3C2PARP1MGLLMMP12PDE3B
SCHEMBL3888548 0.75 ALDH1A1 (0.44) NR3C2MGLLTRPV1
SCHEMBL3888550 0.75 ALDH1A1 (0.44) NR3C2MGLLTRPV1
SCHEMBL21385007 0.71 NR3C2 (0.37) NR3C2PARP1MGLLMMP12
SCHEMBL7455647 0.71 MAPT (0.39) NR3C2MGLLTRPV1
SCHEMBL7455653 0.71 MAPT (0.39) NR3C2MGLLTRPV1
SCHEMBL1190598 0.70 MMP12 (0.53) NR3C2PARP1MGLLMMP12PDE3B
SCHEMBL21385008 0.70 GRM5 (0.32) AKR1C3
SCHEMBL10285580 0.70 PARP1 (0.56) NR3C2PARP1MGLLMMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3768675-B1 NOVEL TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORP (KR) 2026-04-01 EP disclosed
US-11780830-B2 Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same YUHAN CORPORATION (KR) 2023-10-10 US disclosed
US-20210317110-A1 TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORPORATION (KR) 2021-10-14 US disclosed
US-10995086-B2 Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same YUHAN CORPORATION (KR) 2021-05-04 US disclosed
US-20190322655-A1 NOVEL TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORPORATION (KR) 2019-10-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190322655-A1 NOVEL TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME SLC10A1, VAPB, VAT1 NR3C2 1748/4885PARP1 4424/4885MGLL 1247/4885
US-20210317110-A1 TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME SLC10A1, VAT1, LIPC NR3C2 1951/4885PARP1 3385/4885MGLL 1638/4885
US-11780830-B2 Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same SLC10A1, VAT1, LIPC NR3C2 1951/4885PARP1 3385/4885MGLL 1638/4885
US-10995086-B2 Triazolone derivatives or salts thereof and pharmaceutical compositions comprising the same SLC10A1, VAT1, VAPB NR3C2 1856/4885PARP1 3485/4885MGLL 1888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.