Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | PNP | P00491 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1271646 | 0.89 | CDK1 (0.56) | CDK1CDK4CDK2PNPMAPT | |
| Hydrochloric Acid SCHEMBL12474436 | 0.87 | CDK1 (0.54) | CDK1CDK4CDK2PNPMAPT | |
| SCHEMBL3180710 | 0.71 | CDK1 (0.52) | CDK1CDK4CDK2PNPMAPT | |
| Sulfuric Acid SCHEMBL9007348 | 0.71 | CHEK1 (0.34) | CDK2PNPMAPTALDH1A1MEN1 | |
| SCHEMBL7167384 | 0.69 | CDK1 (0.54) | CDK1CDK4CDK2PNPMAPT | |
| Sulfuric Acid SCHEMBL121743 | 0.67 | PDPK1 (0.34) | CDK2MAPTTSHR | |
| Sulfuric Acid SCHEMBL4612293 | 0.67 | PDPK1 (0.34) | CDK2MAPTTSHR | |
| Sulfuric Acid SCHEMBL20815930 | 0.67 | PDPK1 (0.34) | CDK2MAPTTSHR | |
| SCHEMBL12956972 | 0.67 | CDK1 (0.52) | CDK1CDK4CDK2PNPMAPT | |
| SCHEMBL4570268 | 0.67 | PNP (0.46) | CDK1CDK4CDK2PNPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115286584-B | Preparation method of 2,4, 5-triamino-6-hydroxypyrimidine sulfate | 宁波丰谊实业有限公司 | 2023-12-26 | — | — | CN | claimed |
| US-12357634-B2 | 2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2025-07-15 | — | — | US | disclosed |
| CN-119327395-A | Folic acid preparation device | 麦迪海药业有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-118373825-A | Method for recycling formamide solvent in guanine preparation process | 武汉爱科特创生物科技有限公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-112218858-B | 2, 6-Diamino-3, 4-dihydropyrimidin-4-one derivatives and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2024-06-18 | — | — | CN | disclosed |
| CN-117305388-B | Application of bacillus bailii SL-K2 in preparation of guanine extract, preparation method of guanine extract and application | 青岛日晟源作物营养有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-109621860-B | Stirring device, reaction tank for synthesizing folic acid and folic acid synthesizing method | 河北冀衡药业股份有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-117305388-A | Application of bacillus bailii SL-K2 in preparation of guanine extract, preparation method of guanine extract and application | 青岛日晟源作物营养有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-115286584-B | Preparation method of 2,4, 5-triamino-6-hydroxypyrimidine sulfate | 宁波丰谊实业有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112946095-B | Method for detecting chloroacetone compounds in folic acid | 杭州仟源保灵药业有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |
| CN-114380832-B | One-step synthesis method of guanine | 湖北李泽园医药科技有限公司 | 2023-06-16 | — | — | CN | disclosed |
| US-20230110478-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2023-04-13 | — | — | US | disclosed |
| US-11504368-B2 | 2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2022-11-22 | — | — | US | disclosed |
| US-20210052587-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | MEDICINSK FORSKNING (SE) | 2021-02-25 | — | — | US | disclosed |
| EP-3781554-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | Thomas Helledays stiftelse för medicinsk forskning (SE) | 2021-02-24 | — | — | EP | disclosed |
| CN-112218858-A | 2, 6-diamino-3, 4-dihydropyrimidin-4-one derivatives and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2021-01-12 | — | — | CN | disclosed |
| WO-2019201991-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11504368-B2 | 2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy | IL2, THPO, IL6 | CDK1 2239/4885CDK4 1117/4885CDK2 972/4885 |
| US-20230110478-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | IL2, THPO, IL6 | CDK1 2146/4885CDK4 1263/4885CDK2 1026/4885 |
| US-12357634-B2 | 2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy | IL2, THPO, IL6 | CDK1 2146/4885CDK4 1263/4885CDK2 1026/4885 |
| US-20210052587-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | IL2, THPO, IL6 | CDK1 2239/4885CDK4 1117/4885CDK2 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.