Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MGMT | P16455 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21380878 | 0.77 | PIN1 (0.46) | PIN1ALDH1A1L3MBTL1PDE5ASLC6A4 | |
| SCHEMBL29565195 | 0.77 | PIN1 (0.46) | PIN1ALDH1A1L3MBTL1PDE5ASLC6A4 | |
| SCHEMBL22851668 | 0.75 | MRGPRX4 (0.43) | PIN1L3MBTL1MRGPRX4SLC6A4MAPK1 | |
| SCHEMBL31304967 | 0.75 | TRPV1 (0.43) | PIN1ALDH1A1L3MBTL1MRGPRX4PDE5A | |
| SCHEMBL18338730 | 0.73 | PIN1 (0.56) | PIN1L3MBTL1MRGPRX4PDE5ASLC6A4 | |
| SCHEMBL2531398 | 0.72 | TRPV1 (0.46) | PIN1L3MBTL1PDE5AMGMTCDK1 | |
| SCHEMBL21516371 | 0.72 | CTSC (0.49) | HPGDHTTEPHX2MEN1KMT2A | |
| SCHEMBL2527923 | 0.71 | MAOB (0.48) | L3MBTL1SLC6A4CNR1TRPV1 | |
| SCHEMBL15133693 | 0.71 | L3MBTL1 (0.42) | PIN1ALDH1A1L3MBTL1MRGPRX4PDE5A | |
| SCHEMBL1970895 | 0.71 | POLB (0.47) | PIN1ALDH1A1L3MBTL1PDE5ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| EP-3781165-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | Virginia Tech Intellectual Properties, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| CN-112261941-A | Aminopyrazines and related compounds useful as mitochondrial uncouplers | 弗吉尼亚理工大学知识产权有限公司 | 2021-01-22 | — | — | CN | disclosed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | GLS2, NDUFAF1, NDUFAB1 | PIN1 3155/4885ALDH1A1 650/4885L3MBTL1 1532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.