Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 6/20 | 0.48 |
| ▸ | BCR | P11274 | 6/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21497143 | 0.76 | CTSC (0.48) | CTSCABL1BCRDHODHEPHX2 | |
| SCHEMBL6038480 | 0.72 | CCR4 (0.55) | AR | |
| SCHEMBL21497152 | 0.72 | PIN1 (0.43) | EPHX2MEN1KMT2AHPGDHTT | |
| SCHEMBL23163728 | 0.71 | CTSC (0.44) | CTSCABL1BCRIGF1RKMT2A | |
| SCHEMBL5784957 | 0.70 | MRGPRX4 (0.63) | EPHX2MAPTSMN1; SMN2RAB9A | |
| SCHEMBL29230393 | 0.69 | HDAC3 (0.45) | CTSCABL1BCREGFRAURKB | |
| SCHEMBL30944965 | 0.69 | HDAC3 (0.45) | CTSCABL1BCREGFRAURKB | |
| SCHEMBL17432138 | 0.68 | MAPT (0.61) | CTSCABL1BCRDHODHEPHX2 | |
| SCHEMBL21497147 | 0.68 | KCNH2 (0.49) | CTSCABL1BCRNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8933839 | 0.67 | EGFR (0.73) | ABL1BCREGFRAURKBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | claimed |
| CN-112261941-A | Aminopyrazines and related compounds useful as mitochondrial uncouplers | 弗吉尼亚理工大学知识产权有限公司 | 2021-01-22 | — | — | CN | claimed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| CN-112261941-A | Aminopyrazines and related compounds useful as mitochondrial uncouplers | 弗吉尼亚理工大学知识产权有限公司 | 2021-01-22 | — | — | CN | disclosed |
| WO-2019204819-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253538-A1 | AMINOPYRAZINES AND RELATED COMPOUNDS USEFUL AS MITOCHONDRIAL UNCOUPLERS | GLS2, NDUFAF1, NDUFAB1 | CTSC 3218/4885ABL1 2636/4885BCR 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.