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GRB7

Growth factor receptor-bound protein 7 · Q14451 · GRB7 on Sugi Atlas →

306 patent compounds predicted against GRB7, 192 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL22963743 SCHEMBL22963743 0.45 3/20
SCHEMBL29397532 SCHEMBL29397532 0.45 3/20
SCHEMBL29026141 SCHEMBL29026141 0.44 3/20
SCHEMBL2993011 SCHEMBL2993011 0.42 3/20
SCHEMBL2993013 SCHEMBL2993013 0.42 3/20
SCHEMBL15748405 SCHEMBL15748405 0.85 2/20
SCHEMBL15748376 SCHEMBL15748376 0.72 2/20
SCHEMBL15748380 SCHEMBL15748380 0.70 2/20
SCHEMBL14096793 SCHEMBL14096793 0.59 2/20
SCHEMBL14096800 SCHEMBL14096800 0.59 2/20
SCHEMBL14817101 SCHEMBL14817101 0.59 2/20
SCHEMBL14817102 SCHEMBL14817102 0.57 2/20
SCHEMBL20756627 SCHEMBL20756627 0.56 2/20
SCHEMBL21664063 SCHEMBL21664063 0.54 2/20
SCHEMBL22404440 SCHEMBL22404440 0.50 2/20
SCHEMBL22404465 SCHEMBL22404465 0.50 2/20
SCHEMBL23104927 SCHEMBL23104927 0.49 2/20
SCHEMBL25455469 SCHEMBL25455469 0.48 2/20
SCHEMBL25457756 SCHEMBL25457756 0.48 2/20
SCHEMBL15317804 SCHEMBL15317804 0.48 2/20

Clinical trials — most relevant to GRB7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Tumor Gene Expression in Women With Ovarian Cancer PHASE4COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room PHASE2/PHASE3COMPLETED
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer PHASE2COMPLETED
Clinical Trial of BP1001 in Combination With With Venetoclax Plus Decitabine in AML PHASE2RECRUITING
Postoperative EGFR-TKI Therapy forContralateral Pulmonary Nodules in Patients With EGFR-Mutant NSCLC（ARMOR2501） PHASE2RECRUITING
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) PHASE2COMPLETED
Neoadjuvant GW572016 to Treat Breast Cancer PHASE2COMPLETED
Clinical Trial of BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDS PHASE1COMPLETED
Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV) PHASE1COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Pathological and Nuclear Medicine Factors for Prognosis in Lung Carcinoma nanCOMPLETED
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Genetic Polymorphism of the Androgen Receptor-Gene and Sexual Function in Middle Aged Women nanCOMPLETED
Blood and Tissue Study of Patients in NIH Protocol 08-C-0800 nanCOMPLETED
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome nanACTIVE_NOT_RECRUITING
Genetic Predictors of Lithium Response in Bipolar Disorder nanCOMPLETED
Effects of an Amino Acid-Based hGH Secretagogue on Triiodythyronine nanCOMPLETED
Changes in Skin Innervation of Neurologically Asymptomatic Type 2 Diabetic Patients: the Correlation With the Diabetic Parameters and Neurotrophins. nanUNKNOWN
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Novel Biomarkers in Inflammatory Bowel Disease nanCOMPLETED
A Retro-/Prospective, Non-interventional, Cohort Study in Adult Patients With Locally Advanced or Metastatic Tumors With a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion, Treated With Larotrectinib nanCOMPLETED
K-RAS Oncogene Mutation in Patients With Advanced Non-Small Cell Lung Cancer Associated With Exposure to Wood Smoke and Tobacco Smoking: Therapeutic Implications nanCOMPLETED
Family Blood Pressure Program - GenNet Network nanCOMPLETED
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GRB7 binder may also engage these)

ProteinNameSimilarity
Q03160 — 1.000 Q03160 →
Q9QZC5 — 1.000 Q9QZC5 →
Q1RMW5 — 1.000 Q1RMW5 →
B5KFD7 — 1.000 B5KFD7 →
Q13322 — 0.992 Q13322 →
Q9JLM9 — 0.991 Q9JLM9 →
Q9BST9 — 0.990 Q9BST9 →
O88900 — 0.990 O88900 →
Q5ICW4 — 0.988 Q5ICW4 →
Q8C6B2 — 0.987 Q8C6B2 →
Q14449 — 0.987 Q14449 →
A7UA95 — 0.986 A7UA95 →
Q9BZF2 — 0.985 Q9BZF2 →
Q14B98 — 0.984 Q14B98 →
B2RYG7 — 0.984 B2RYG7 →
Q9UGK3 — 0.984 Q9UGK3 →
Q0QWG9 — 0.984 Q0QWG9 →
Q8R0L1 — 0.983 Q8R0L1 →
Q5TJE5 — 0.983 Q5TJE5 →
Q6V7V2 — 0.983 Q6V7V2 →
Q9BXL6 — 0.983 Q9BXL6 →
Q60760 — 0.983 Q60760 →
Q8BL80 — 0.982 Q8BL80 →
RNF31 E3 ubiquitin-protein ligase RNF31 0.982 landscape →
Q9ULM0 — 0.982 Q9ULM0 →
B5DFA1 — 0.982 B5DFA1 →
O94887 — 0.982 O94887 →
O43304 — 0.981 O43304 →
Q9ESJ4 — 0.981 Q9ESJ4 →
Q61235 — 0.981 Q61235 →