Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21497779 | 0.79 | PTGDR2 (0.72) | LMNAPOLBPTGDR2MAPK1L3MBTL1 | |
| SCHEMBL9213633 | 0.76 | ADRB2 (0.48) | KDM4EALDH1A1PTGDR2MAPK1RAB9A | |
| SCHEMBL9206767 | 0.74 | KDM4E (0.49) | KDM4EHPGDHTTALDH1A1HSD17B10 | |
| SCHEMBL5310309 | 0.73 | KDM4E (0.51) | KDM4EHPGDHTTALDH1A1LMNA | |
| SCHEMBL1046904 | 0.73 | KDM4E (0.51) | KDM4EHPGDHTTALDH1A1LMNA | |
| SCHEMBL28337685 | 0.73 | KDM4E (0.51) | KDM4EHPGDHTTALDH1A1LMNA | |
| SCHEMBL8410488 | 0.73 | LMNA (0.60) | KDM4EHTTALDH1A1LMNAMAPT | |
| SCHEMBL8670844 | 0.72 | MMP3 (0.69) | KDM4EALDH1A1PTGDR2 | |
| SCHEMBL10475269 | 0.72 | RECQL (0.71) | KDM4EHPGDHTTALDH1A1USP2 | |
| SCHEMBL15332808 | 0.70 | PTGDR2 (0.59) | HPGDHTTALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450303-B2 | Biaryl piperidine amide compounds and methods of use thereof | ATHENEX, INC. (US) | 2019-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450303-B2 | Biaryl piperidine amide compounds and methods of use thereof | AADAC, PAICS, UGT2B7 | KDM4E 2535/4885HPGD 939/4885ABCB1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.