Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.67 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.67 |
| ▸ | PLK1 | P53350 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MLYCD | O95822 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12672300 | 0.87 | ASAH2 (0.63) | PLK1ALDH1A1LMNACYP1A2ALOX15 | |
| SCHEMBL14380335 | 0.85 | TAS1R3 (0.67) | TAS1R3TAS1R1PLK1ALDH1A1LMNA | |
| SCHEMBL22259696 | 0.85 | PLK1 (0.60) | TAS1R3TAS1R1PLK1ALDH1A1LMNA | |
| SCHEMBL16982004 | 0.84 | KMT2A (0.59) | TAS1R3TAS1R1PLK1ALDH1A1LMNA | |
| SCHEMBL8590217 | 0.82 | MLYCD (0.70) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL3363186 | 0.81 | ALDH1A1 (0.65) | TAS1R3TAS1R1ALDH1A1LMNACYP1A2 | |
| SCHEMBL4197725 | 0.81 | TAS1R3 (1.00) | TAS1R3TAS1R1PLK1CTSS | |
| SCHEMBL4197727 | 0.81 | TAS1R3 (1.00) | TAS1R3TAS1R1PLK1CTSS | |
| SCHEMBL23513432 | 0.80 | PTGS2 (0.63) | TAS1R3TAS1R1ALDH1A1LMNACYP1A2 | |
| SCHEMBL2643888 | 0.80 | ALDH1A1 (0.63) | TAS1R3TAS1R1ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059826-B2 | Pteridinone compounds and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-07-13 | — | — | US | disclosed |
| US-20190322673-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322673-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | DPYD, PKD1, TYMP | TAS1R3 3945/4885TAS1R1 2911/4885PLK1 340/4885 |
| US-11059826-B2 | Pteridinone compounds and uses thereof | DPYD, PKD1, TYMP | TAS1R3 3945/4885TAS1R1 2911/4885PLK1 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.