Maleic Acid

Maleic Acid

SCHEMBL215107

O=C(O)/C=C\C(=O)O.OCCO.OCCO

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol

The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.69
TP53 P04637 1/20 0.69
EGLN1 Q9GZT9 1/20 0.69
EGLN3 Q9H6Z9 1/20 0.69
GABRR1 P24046 2/20 0.45
GABRR2 P28476 2/20 0.45
BLM P54132 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
LMNA P02545 2/20 0.45
GABRR3 A8MPY1 1/20 0.45
APEX1 P27695 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
HCAR2 Q8TDS4 6/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
ALDH1A1 P00352 3/20 0.38
GAA P10253 1/20 0.38
ALOX15 P16050 1/20 0.38
RECQL P46063 1/20 0.38
HSD17B10 Q99714 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL10780619 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Fumaric Acid SCHEMBL27990610 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Fumaric Acid SCHEMBL22117153 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Maleic Acid SCHEMBL2525505 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Maleic Acid SCHEMBL28461661 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Fumaric Acid SCHEMBL303957 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Maleic Acid SCHEMBL27945335 1.00 TSHR (0.69) TSHRTP53EGLN1EGLN3GABRR1
Fumaric Acid SCHEMBL865153 0.87 LMNA (0.59) TSHRTP53EGLN1EGLN3GABRR1
Maleic Acid SCHEMBL27937602 0.87 HCAR2 (0.55) TSHRTP53EGLN1EGLN3GABRR1
Maleic Acid SCHEMBL28208249 0.87 LMNA (0.59) TSHRTP53EGLN1EGLN3GABRR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105542091-A Slow-release cationic anti-mud polycarboxylic-type high performance water reducer and preparation method thereof GUANGDONG FUTE NEW MAT TECH CO LTD 2016-05-04 CN claimed
CN-104230203-B A kind of super sustained-release polycarboxylic slump retaining agent and preparation method thereof BEIJING ORIENTAL YUHONG WATERPROOF TECHNOLOGY CO., LTD. (CN) 2016-04-27 CN claimed
CN-105503012-A Composition used for producing slow release anti-mud polycarboxylate-type water reducing agent GUANGDONG FUTE NEW MAT TECH CO LTD 2016-04-20 CN claimed
CN-104230203-A Super controlled release type polycarboxylate slump retention agent and preparation method thereof BEIJING ORIENTAL YUHONG WATERPROOF TECHNOLOGY CO LTD 2014-12-24 CN claimed
CN-102226007-B Double network polymer hydrogel and preparation method thereof UNIV XIAMEN 2012-09-05 CN claimed
CN-102226007-A Double network polymer hydrogel and preparation method thereof UNIV XIAMEN 2011-10-26 CN claimed
US-5874148-A Water resistant textile coating and method of using the same REICHHOLD CHEMICALS, INC. (US) 1999-02-23 US claimed
US-5684052-A RECYCLING, TUFT-LOCK COATING, EXTRUSION REICHHOLD CHEMICALS, INC. (US) 1997-11-04 US claimed
US-5505999-A APPLYING COATING OF NON-AROMATIC UNSATURATED MONO OR DICARBOXYLIC ESTER AND ALIPHATIC CONJUGATED DIENE MONOMERS, ON THE SURFACE OF SUBSTRATE, HEATING TO DRY THE COATING REICHHOLD CHEMICALS, INC. (US) 1996-04-09 US claimed
US-5502138-A UNSATURATED MONO OR DIESTERS AND CONJUGATED DIENE FOR TEXTILES REICHHOLD CHEMICALS, INC. (US) 1996-03-26 US claimed
US-5378755-A Textile print paste, copolymer of butadiene and an acrylic ester, colorfast, washfast REICHHOLD CHEMICALS, INC. (US) 1995-01-03 US claimed
US-4950711-A CONJUGATED DIENE, MONOOLEFIN, AND UNSATURATED CARBOXYLIC ACID MONOMERS REICHHOLD CHEMICALS, INC. (US) 1990-08-21 US claimed
JP-59053835-A None JP disclosed
WO-2024106435-A1 AQUEOUS LUMINOUS PIGMENT COMPOSITION 日本エイアンドエル株式会社 2024-05-23 WO disclosed
EP-3778676-B1 METHOD FOR PRODUCING CONJUGATED-DIENE-BASED COPOLYMER LATEX NIPPON A&L INC (JP) 2023-10-11 EP disclosed
WO-2023167259-A1 METHOD FOR PRODUCING LAMINATION MOLDED ARTICLE, HEAT-SENSITIVE GELLING AGENT, AND LAMINATION MOLDING COMPOSITION 日本エイアンドエル株式会社 2023-09-07 WO disclosed
US-4056670-A Anaerobic adhesive and sealant compositions employing as a catalyst α- NATIONAL STARCH AND CHEMICAL CORPORATION (US) 1977-11-01 US disclosed
US-4054480-A AS A CATALYST, ACRYLIC POLYMERS NATIONAL STARCH AND CHEMICAL CORPORATION (US) 1977-10-18 US disclosed
US-4052244-A ACRYLIC AND SACCHARIN COMPOUND, P-TOLUENESULFINATE NATIONAL STARCH AND CHEMICAL CORPORATION (US) 1977-10-04 US disclosed
US-3957561-A Anaerobic adhesive and sealant compositions employing a two component catalyst system of diazosulfone and o-sulfobenzimide NATIONAL STARCH AND CHEMICAL CORPORATION (US) 1976-05-18 US disclosed