Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.45 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10780619 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL27990610 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL22117153 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL2525505 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28461661 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL215107 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL27945335 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL865153 | 0.87 | LMNA (0.59) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL27937602 | 0.87 | HCAR2 (0.55) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28208249 | 0.87 | LMNA (0.59) | TSHRTP53EGLN1EGLN3GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119592148-A | High-speed coated electrochemical aluminum color layer coating and preparation method thereof | 佛山市金镭科技有限公司 | 2025-03-11 | — | — | CN | claimed |
| CN-119039766-B | Environment-friendly high-elasticity polyurethane modified acrylic track surface adhesive and preparation method thereof | 湖南优冠体育材料有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-119350713-A | Preparation method of environment-friendly stabilizer for high-calcium PVC (polyvinyl chloride) product | 山东金昌树新材料股份有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119081446-A | Preparation method of high-purity gardenia yellow pigment | 河南中大恒源生物科技股份有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-119039766-A | Environment-friendly high-elasticity polyurethane modified acrylic track surface adhesive and preparation method thereof | 湖南优冠体育材料有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-117079959-B | Magnetic nano material for detecting glycoprotein and preparation method thereof | 四川赛尔医学检验有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-115490920-B | Preparation of nanoparticle-loaded ionic liquid and functional modified polylactic acid material | 安徽元梦生物基材料科技有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-117079959-A | Magnetic nano material for detecting glycoprotein and preparation method thereof | 四川赛尔医学检验有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-111793174-B | Normal-temperature synthesis method of multi-initiated slow-release slump-retaining polycarboxylate superplasticizer | 贵州石博士科技股份有限公司 | 2023-06-20 | — | — | CN | claimed |
| CN-114805855-B | Bioactive hydrogel with controllable charges and preparation method and application thereof | 华中科技大学同济医学院附属同济医院 | 2023-03-10 | — | — | CN | claimed |
| CN-108003305-B | Synthetic method of polycarboxylate superplasticizer | 北京砼帮汇科技有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-111793174-A | Normal-temperature synthesis method of multi-element-initiated slow-release slump-retaining polycarboxylic acid water reducer | 贵州石博士科技有限公司 | 2020-10-20 | — | — | CN | claimed |
| WO-2020128904-A1 | COMPOSITION INCLUDING POLYESTER RESIN AND VINYL ESTER AND METHOD OF USING THE SAME | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2020-06-25 | — | — | WO | claimed |
| EP-1874525-B1 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | MAYO FOUNDATION (US) | 2011-06-01 | — | — | EP | claimed |
| US-7727554-B2 | Sustained-release nanoparticle compositions and methods for using the same | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA BY AND BEHALF OF THE UNIVERSITY OF NEBRASKA MEDICAL CENTER (US) | 2010-06-01 | — | — | US | claimed |
| EP-1874525-A4 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | MAYO FOUNDATION (US) | 2009-05-27 | — | — | EP | claimed |
| US-20080262102-A1 | Biodegradable polymer scaffolds for skeletal reconstruction; hydrogels with controllable hydrophilicity, swelling, mechanical properties; biocompatible, bioresorbable, injectable, and in-situ hardening; tissue engineering and controlled drug release; photocrosslinking; surgerical handling/positioning | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2008-10-23 | — | — | US | claimed |
| EP-1874525-A1 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | Mayo Foundation for Medical Education and Research (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006118987-A1 | HYDROPHILIC/HYDROPHOBIC POLYMER NETWORKS BASED ON POLY(CAPROLACTONE FUMARATE), POLY(ETHYLENE GLYCOL FUMARATE), AND COPOLYMERS THEREOF | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2006-11-09 | — | — | WO | claimed |
| US-4212790-A | Resin concrete composition | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1980-07-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262102-A1 | Biodegradable polymer scaffolds for skeletal reconstruction; hydrogels with controllable hydrophilicity, swelling, mechanical properties; biocompatible, bioresorbable, injectable, and in-situ hardening; tissue engineering and controlled drug release; photocrosslinking; surgerical handling/positioning | PLOD1, CPT1B, PLOD3 | MEN1 4130/4885KMT2A 4803/4885TSHR 3503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.