Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.45 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10780619 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL27990610 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL22117153 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28461661 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL215107 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL303957 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL27945335 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Fumaric Acid SCHEMBL865153 | 0.87 | LMNA (0.59) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL27937602 | 0.87 | HCAR2 (0.55) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28208249 | 0.87 | LMNA (0.59) | TSHRTP53EGLN1EGLN3GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113637123-B | Hyperbranched concrete tackifier and preparation method and application thereof | 武汉源锦建材科技有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-111977815-B | Biodegradable water treatment agent | 科威天使环保科技集团股份有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-116003699-A | Viscosity-reducing polycarboxylic acid slump retaining agent and preparation method thereof | 陕西科之杰新材料有限公司 | 2023-04-25 | — | — | CN | claimed |
| CN-115109574-A | Surfactant for improving recovery rate in fracturing fluid system and preparation method thereof | 沧州中润化学助剂有限公司 | 2022-09-27 | — | — | CN | claimed |
| CN-112176349-B | Non-phosphorus corrosion inhibitor composition, non-phosphorus corrosion inhibitor and application thereof | 中国石油化工股份有限公司 | 2022-05-17 | — | — | CN | claimed |
| CN-113354333-B | Hyperbranched water-reducing viscosity-reducing concrete admixture and preparation method and application thereof | 中南大学 | 2022-05-03 | — | — | CN | claimed |
| CN-111587128-B | Synthesis and characterization of well-defined polypropylene fumarate and polyethylene glycol block copolymers | 阿克伦大学 | 2022-04-15 | — | — | CN | claimed |
| CN-114181355-A | Ester-ether mixed viscosity-reducing polycarboxylate superplasticizer and preparation method thereof | 陕西科之杰新材料有限公司 | 2022-03-15 | — | — | CN | claimed |
| CN-114163579-A | Viscosity-reducing water-retaining polycarboxylate superplasticizer and preparation method thereof | 陕西科之杰新材料有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114149546-A | Viscosity-reducing polycarboxylate superplasticizer and preparation method thereof | 史才军 | 2022-03-08 | — | — | CN | claimed |
| CN-104744619-A | Method for preparing carboxylic butadiene-styrene latex for coated white board paper by virtue of soap-free polymerization | QUANZHOU DELI CHEMICAL CO LTD | 2015-07-01 | — | — | CN | claimed |
| CN-104725542-A | Method for preparing high-performance styrene-acrylic latex used for space cotton | QUANZHOU DELI CHEMICAL CO LTD | 2015-06-24 | — | — | CN | claimed |
| CN-104414912-A | Hand sanitizer for treating leuconychia | ASIA PACIFIC LIGHT ALLOY NANTONG TECHNOLOGY CO LTD | 2015-03-18 | — | — | CN | claimed |
| CN-104414882-A | Hand washing solution for treating onychomycosis | NANTONG TONGZHOU DISTR YUESHUO AGRICULTURE DEV CO LTD | 2015-03-18 | — | — | CN | claimed |
| CN-103816082-A | Hand cleanser for treating onychomycosis | NANTONG HAISHUN CHEMICAL CO LTD | 2014-05-28 | — | — | CN | claimed |
| CN-103374090-A | Method for preparing carboxyl styrene-butadiene latex for artificial turf back coating through soap-free polymerization | QUANZHOU DELI CHEMICAL CO LTD | 2013-10-30 | — | — | CN | claimed |
| CN-102772335-A | Antibacterial protecting hand sanitizer | JIANGSU XINSHI PREC CHEMICAL CO LTD | 2012-11-14 | — | — | CN | claimed |
| CN-1196735-C | Process for making fluorinated polymer adsorbent particles | PROMETRIC BIOSCIENCES INC (CA) | 2005-04-13 | — | — | CN | claimed |
| CN-1593661-A | Injectable pharmaceutical slow-release carrier and preparation method thereof | UNIV HUAZHONG SCIENCE TECH (CN) | 2005-03-16 | — | — | CN | claimed |
| CN-1359407-A | Process for making fluorinated polymer adsorbent particles | PROMETRIC BIOSCIENCES INC (CA) | 2002-07-17 | — | — | CN | claimed |