Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2153002 | 1.00 | OPRK1 (0.44) | OPRK1IDO1CYP1A2CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL7261643 | 0.98 | OPRK1 (0.44) | OPRK1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2153393 | 0.86 | SCN9A (0.47) | IDO1NOS3NOS1NOS2KMT2A | |
| SCHEMBL2153399 | 0.86 | SCN9A (0.47) | IDO1NOS3NOS1NOS2KMT2A | |
| SCHEMBL10564172 | 0.83 | ITGA4 (0.41) | OPRK1IDO1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2502292 | 0.82 | NLRP3 (0.45) | OPRK1IDO1CYP2D6NOS3NOS1 | |
| SCHEMBL2586006 | 0.82 | NLRP3 (0.45) | OPRK1IDO1CYP2D6NOS3NOS1 | |
| SCHEMBL22113081 | 0.82 | NLRP3 (0.45) | OPRK1IDO1CYP2D6NOS3NOS1 | |
| SCHEMBL28741496 | 0.82 | DPP4 (0.45) | OPRK1NOS3NOS1NOS2KIF11 | |
| SCHEMBL29478100 | 0.82 | NLRP3 (0.45) | OPRK1IDO1CYP2D6NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833789-B1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED INDOLINE-2-CARBOXYLIC ACID | DSM IP ASSETS BV (NL) | 2011-07-06 | — | — | EP | disclosed |
| CN-101090886-B | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acids | DSM IP ASSETS BV | 2011-05-18 | — | — | CN | disclosed |
| US-7732621-B2 | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid | DSM IP ASSETS B.V. (NL) | 2010-06-08 | — | — | US | disclosed |
| EP-2069518-B1 | METHOD FOR PRODUCING OPTICALLY ACTIVE PHENYLALANINE COMPOUNDS FROM CINNAMIC ACID DERIVATIVES EMPLOYING A PHENYLALANINE AMMONIA LYASE DERIVED FROM IDIOMARINA LOIHIENSIS | DSM IP ASSETS BV (NL) | 2010-02-03 | — | — | EP | disclosed |
| CN-101517089-A | Method for producing optically active phenylalanine compound from cinnamic acid derivative using phenylalanine ammonia lyase derived from Idiomarina loihiensis | DSM IP ASSETS BV (NL) | 2009-08-26 | — | — | CN | disclosed |
| EP-2069518-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE PHENYLALANINE COMPOUNDS FROM CINNAMIC ACID DERIVATIVES EMPLOYING A PHENYLALANINE AMMONIA LYASE DERIVED FROM IDIOMARINA LOIHIENSIS | DSMIP Assets B.V. (NL) | 2009-06-17 | — | — | EP | disclosed |
| US-20090043112-A1 | Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid | DSM IP ASSETS B.V. (NL) | 2009-02-12 | — | — | US | disclosed |
| WO-2008031578-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE PHENYLALANINE COMPOUNDS FROM CINNAMIC ACID DERIVATIVES EMPLOYING A PHENYLALANINE AMMONIA LYASE DERIVED FROM IDIOMARINA LOIHIENSIS | DSM IP ASSETS B.V. (NL) | 2008-03-20 | — | — | WO | disclosed |
| CN-101090886-A | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acids | DSM IP ASSETS BV (NL) | 2007-12-19 | — | — | CN | disclosed |
| EP-1833789-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED INDOLINE-2-CARBOXYLIC ACID | DSMIP Assets B.V. (NL) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069799-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED INDOLINE-2-CARBOXYLIC ACID | DSM IP ASSETS B.V. (NL) | 2006-07-06 | — | — | WO | disclosed |
| EP-1676838-A1 | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid | DSM IP Assets B.V. (NL) | 2006-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090043112-A1 | Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid | IDO2, IDO1, KYNU | OPRK1 86/4885IDO1 2/4885CYP1A2 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.