Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103488 | 0.73 | XDH (0.43) | ARTSHRXDH | |
| SCHEMBL28022369 | 0.70 | ESR2 (0.48) | ARTSHRNPSR1KDM4EALDH1A1 | |
| SCHEMBL6562393 | 0.70 | ESR2 (0.50) | ARTSHRCYP11B2NPSR1KDM4E | |
| SCHEMBL29662920 | 0.70 | ESR2 (0.50) | ARTSHRCYP11B2NPSR1KDM4E | |
| SCHEMBL18190520 | 0.69 | GRIA1 (0.67) | DGAT1GRIA1CACNG8ESR2 | |
| SCHEMBL21533143 | 0.69 | AR (0.40) | ARTSHRALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL14040913 | 0.69 | ESR2 (0.54) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL30550569 | 0.69 | ESR2 (0.44) | ARCYP11B2KDM4EALDH1A1HPGD | |
| SCHEMBL9630722 | 0.69 | HSD17B1 (0.42) | TSHRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL21973781 | 0.69 | DHODH (0.38) | ARCYP11B2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |