Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946583 | 0.83 | SIRT3 (0.60) | SIRT3TDP1BMPR1AACVR1BTGFBR1 | |
| SCHEMBL28859980 | 0.82 | KDM4E (0.48) | SIRT3TDP1MAP4K1KDM6BFTO | |
| SCHEMBL19523059 | 0.79 | TGFBR1 (0.53) | SIRT3TDP1BMPR1AACVR1BTGFBR1 | |
| SCHEMBL9002466 | 0.79 | SIRT3 (0.61) | SIRT3TDP1KDM6BCYP2D6CYP2A6 | |
| SCHEMBL29417505 | 0.77 | ALDH1A1 (0.60) | SIRT3TDP1BMPR1AACVR1BTGFBR1 | |
| SCHEMBL6626544 | 0.74 | TDP1 (0.46) | SIRT3TDP1KDM6BCYP2D6CYP2A6 | |
| SCHEMBL3818724 | 0.73 | TDP1 (0.44) | SIRT3TDP1KDM6BCYP2D6CYP2A6 | |
| SCHEMBL30465694 | 0.73 | KDM4C (0.51) | SIRT3TDP1KDM6BCYP2D6CYP2A6 | |
| SCHEMBL123203 | 0.73 | KDM4C (0.51) | SIRT3TDP1KDM6BCYP2D6CYP2A6 | |
| SCHEMBL11926757 | 0.73 | TDP1 (0.50) | SIRT3TDP1BMPR1AACVR1BTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780823-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20230047396-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| US-11066388-B2 | Indazole-3-carboxamides and their use as WNT/B-catenin signaling pathway inhibitors | BIOSPLICE THERAPEUTICS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200239436-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2020-07-30 | — | — | US | disclosed |
| US-10464924-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | SAMUMED, LLC (US) | 2019-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047396-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | WNT1, WNT3, WNT3A | SIRT3 68/4885TDP1 3724/4885BMPR1A 858/4885 |
| US-20200239436-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | WNT1, WNT3, WNT3A | SIRT3 68/4885TDP1 3724/4885BMPR1A 858/4885 |
| US-10464924-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | WNT1, WNT3, WNT3A | SIRT3 47/4885TDP1 3518/4885BMPR1A 1122/4885 |
| US-11066388-B2 | Indazole-3-carboxamides and their use as WNT/B-catenin signaling pathway inhibitors | WNT1, WNT3, WNT3A | SIRT3 68/4885TDP1 3724/4885BMPR1A 858/4885 |
| US-11780823-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | WNT1, WNT3, WNT3A | SIRT3 47/4885TDP1 3518/4885BMPR1A 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.