Sugi Predict

Sugi Predict / Compounds / SCHEMBL2154106

SCHEMBL2154106

SCHEMBL2154106

Clc1cc[c]c(Cc2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ HIF1A Q16665 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ CALM1 P0DP23 1/20 0.41
▸ PGR P06401 1/20 0.39
▸ SIGMAR1 Q99720 3/20 0.37
▸ PNMT P11086 1/20 0.35
▸ BCL2 P10415 1/20 0.35
▸ BCL2L1 Q07817 1/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ TAAR1 Q96RJ0 3/20 0.34
▸ MAPT P10636 1/20 0.34
▸ IDH1 O75874 1/20 0.33
▸ GRIN2B Q13224 1/20 0.33
▸ KCNMA1 Q12791 1/20 0.33
▸ GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8754943 0.86 MEN1 (0.38) MEN1KMT2ACYP3A4HPGDALOX15
SCHEMBL2093279 0.80 CALM1 (0.50) CALM1BCL2BCL2L1IDH1
SCHEMBL4757691 0.77 CALM1 (0.41) MEN1KMT2AHPGDCALM1BCL2
SCHEMBL7014345 0.77 CALM1 (0.41) MEN1KMT2ACYP3A4HPGDALOX15
SCHEMBL8602727 0.77 ALOX5 (0.47) MEN1KMT2ACYP3A4HPGDALOX15
SCHEMBL6981018 0.77 MAOB (0.42) CALM1SIGMAR1BCL2BCL2L1ALDH1A1
SCHEMBL16601111 0.77 CALM1 (0.41) MEN1KMT2AHPGDCALM1BCL2
SCHEMBL2852601 0.77 CALM1 (0.41) MEN1KMT2ACYP3A4CALM1BCL2
SCHEMBL7877438 0.77 CALM1 (0.41) HPGDCALM1BCL2BCL2L1ALDH1A1
SCHEMBL8089580 0.76 TP53 (0.46) CYP3A4CALM1BCL2BCL2L1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2513064-A2 COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2012-10-24 — — EP claimed
WO-2011080132-A2 COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2011-07-07 — — WO claimed
EP-0227980-B1 FLUORESCENT AROXYSUBSTITUTED 3,4,9,10-PERYLENETETRACARBOXYLIC ACID-DIIMIDES AND THEIR USE FOR THE CONCENTRATION OF LIGHTS IN SMALL AREAS BASF Aktiengesellschaft (DE) 1991-10-09 — — EP claimed
EP-0086878-A1 Mild antimicrobial detergent composition Dexide, Inc. (US) 1983-08-31 — — EP claimed
US-3984411-A HYPOCHOLESTEROLEMICS, HYPOGLYCEMICS OR ANTIDIABETICS SOCIETE GENERALE DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES "SOGERAS" (FR) 1976-10-05 — — US claimed
US-10577315-B2 Compositions and methods for treatment of prostate carcinoma PELLFICURE PHARMACEUTICALS, INC. (US) 2020-03-03 — — US disclosed
US-20190169122-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA PELLFICURE PHARMACEUTICALS 2019-06-06 — — US disclosed
US-10093620-B2 Compositions and methods for treatment of prostate carcinoma PELLFICURE PHARMACEUTICALS, INC. (US) 2018-10-09 — — US disclosed
US-20170283374-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA PELLFICURE PHARMACEUTICALS, INC. 2017-10-05 — — US disclosed
EP-3191087-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA Pellficure Pharmaceuticals, Inc. (US) 2017-07-19 — — EP disclosed
EP-3052498-A1 3,7-DIAZABICYCLO[3.3.1]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS Council of Scientific & Industrial Research (IN) 2016-08-10 — — EP disclosed
WO-2016040896-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA PELLFICURE PHARMACEUTICALS, INC. (US) 2016-03-17 — — WO disclosed
US-4336270-A BACTERICIDES, FUNGICIDES CIBA-GEIGY CORPORATION (US) 1982-06-22 — — US disclosed
US-4282369-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1981-08-04 — — US disclosed
US-4226613-A Bisthiocarbamic acid esters and herbicidal use thereof BASF AKTIENGESELLSCHAFT (DE) 1980-10-07 — — US disclosed
US-4227007-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1980-10-07 — — US disclosed
US-4182902-A P-(P'-CHLOROBENZYL) PHENOXYACETIC ACID SIEGFRIED AKTIENGESELLSCHAFT (CH) 1980-01-08 — — US disclosed
US-4153803-A Cholesterol-lowering phenoxyalkanoic acid esters SIEGFRIED AKTIENGESELLSCHAFT (CH) 1979-05-08 — — US disclosed
US-3984411-A HYPOCHOLESTEROLEMICS, HYPOGLYCEMICS OR ANTIDIABETICS SOCIETE GENERALE DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES "SOGERAS" (FR) 1976-10-05 — — US disclosed
US-3956402-A MICROBIOCIDES CIBA-GEIGY CORPORATION (US) 1976-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10093620-B2 Compositions and methods for treatment of prostate carcinoma KLK3, ACP3, NR5A1 MEN1 260/4885KMT2A 3314/4885CYP3A4 1911/4885
US-20190169122-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA KLK3, ACP3, NR5A1 MEN1 260/4885KMT2A 3314/4885CYP3A4 1911/4885
US-20170283374-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA KLK3, ACP3, NR5A1 MEN1 260/4885KMT2A 3314/4885CYP3A4 1911/4885
US-10577315-B2 Compositions and methods for treatment of prostate carcinoma KLK3, ACP3, NR5A1 MEN1 260/4885KMT2A 3314/4885CYP3A4 1911/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.