SCHEMBL7014345

SCHEMBL7014345

Ic1cc[c]c(Cc2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.41
BCL2 P10415 1/20 0.35
BCL2L1 Q07817 1/20 0.35
IDH1 O75874 1/20 0.33
IDO1 P14902 2/20 0.32
HPGD P15428 2/20 0.32
ALOX15 P16050 2/20 0.32
HSD17B10 Q99714 2/20 0.32
ALDH1A1 P00352 1/20 0.32
ALOX12 P18054 1/20 0.32
CASP1 P29466 1/20 0.32
ALOX5 P09917 1/20 0.32
LTA4H P09960 1/20 0.31
HIF1A Q16665 2/20 0.30
DAO P14920 1/20 0.30
MEN1 O00255 1/20 0.30
CYP3A4 P08684 1/20 0.30
KMT2A Q03164 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8939760 0.80 MAOA (0.41) HPGDALOX15HSD17B10ALDH1A1ALOX12
SCHEMBL2093279 0.80 CALM1 (0.50) CALM1BCL2BCL2L1IDH1ALOX5
SCHEMBL8602727 0.77 ALOX5 (0.47) CALM1BCL2BCL2L1IDH1HPGD
SCHEMBL2154106 0.77 MEN1 (0.44) CALM1BCL2BCL2L1IDH1HPGD
SCHEMBL7877438 0.77 CALM1 (0.41) CALM1BCL2BCL2L1IDH1HPGD
SCHEMBL2852601 0.77 CALM1 (0.41) CALM1BCL2BCL2L1IDH1ALDH1A1
SCHEMBL16601111 0.77 CALM1 (0.41) CALM1BCL2BCL2L1IDH1IDO1
SCHEMBL6981018 0.77 MAOB (0.42) CALM1BCL2BCL2L1IDH1ALDH1A1
SCHEMBL4757691 0.77 CALM1 (0.41) CALM1BCL2BCL2L1IDH1IDO1
SCHEMBL8089580 0.76 TP53 (0.46) CALM1BCL2BCL2L1IDH1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1355904-A2 HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS Wyeth (US) 2003-10-29 EP disclosed
WO-2002051837-A2 HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS WYETH (US) 2002-07-04 WO disclosed