SCHEMBL2154604

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2154763	0.89	MAPT (0.62)	MAPTALDH1A1POLBCTDSP1SMN1; SMN2
	SCHEMBL12768313	0.83	MAPT (0.63)	MAPTALDH1A1POLBCTDSP1SMN1; SMN2
	SCHEMBL7279965	0.81	MAPT (0.71)	MAPTALDH1A1POLBSMN1; SMN2KDM4E
	SCHEMBL26758049	0.81	ALDH1A1 (0.53)	MAPTALDH1A1POLBCTDSP1KDM4E
	Niclosamide SCHEMBL7778390	0.78	KMT2A (0.71)	MAPTALDH1A1POLBCTDSP1SMN1; SMN2
	SCHEMBL8477219	0.77	PKM (0.61)	MAPTALDH1A1SMN1; SMN2KDM4EGAA
	Pyrazinamide SCHEMBL27887770	0.74	ALDH1A1 (0.51)	MAPTALDH1A1POLBCTDSP1SMN1; SMN2
	SCHEMBL4360020	0.73	PKM (0.57)	MAPTALDH1A1SMN1; SMN2KDM4EGAA
	SCHEMBL4360014	0.73	PKM (0.57)	MAPTALDH1A1SMN1; SMN2KDM4EGAA
	SCHEMBL23926496	0.72	NPC1 (0.65)	MAPTALDH1A1POLBCTDSP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.