SCHEMBL2154763

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2154604	0.89	MAPT (0.61)	MAPTALDH1A1POLBCTDSP1LMNA
	SCHEMBL12768313	0.84	MAPT (0.63)	MAPTALDH1A1POLBCTDSP1LMNA
	SCHEMBL26758049	0.82	ALDH1A1 (0.53)	MAPTALDH1A1POLBCTDSP1LMNA
	SCHEMBL6834011	0.77	MEN1 (0.51)	MAPTALDH1A1POLBCTDSP1KMT2A
	SCHEMBL11870435	0.76	MAPT (0.71)	MAPTALDH1A1AKR1C4AKR1C3AKR1C2
	Niclosamide SCHEMBL7778390	0.75	KMT2A (0.71)	MAPTALDH1A1POLBCTDSP1LMNA
	SCHEMBL7846339	0.74	MAPT (0.68)	MAPTALDH1A1AKR1C4AKR1C3AKR1C2
	SCHEMBL3279807	0.74	MAPT (0.72)	MAPTALDH1A1AKR1C4AKR1C3AKR1C2
	SCHEMBL1531297	0.73	MAPT (1.00)	MAPTALDH1A1AKR1C4AKR1C3AKR1C2
	SCHEMBL23926496	0.73	NPC1 (0.65)	MAPTALDH1A1POLBCTDSP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.