SCHEMBL21547590

SCHEMBL21547590

C=C(C)Cc1cc(C(C)(C)c2ccccc2)cc(CC)c1OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.39
ALDH1A1 P00352 7/20 0.35
ESR1 P03372 1/20 0.35
CYP3A4 P08684 1/20 0.35
ESR2 Q92731 1/20 0.35
NR3C2 P08235 2/20 0.34
CNR1 P21554 2/20 0.33
CNR2 P34972 2/20 0.33
KDM4E B2RXH2 8/20 0.33
SMN1; SMN2 Q16637 4/20 0.33
NR1I2 O75469 1/20 0.33
CHRM2 P08172 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
ADRA2B P18089 1/20 0.33
SLC6A4 P31645 1/20 0.33
OPRM1 P35372 1/20 0.33
OPRD1 P41143 1/20 0.33
OPRK1 P41145 1/20 0.33
CHRNA4 P43681 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL241385 0.86 ALOX15 (0.37) ELANEALDH1A1CYP3A4HTT
SCHEMBL21547604 0.83 CYP2C19 (0.33) ELANEESR1CYP3A4ESR2SMN1; SMN2
SCHEMBL21547611 0.79 ESR1 (0.46) ELANEALDH1A1ESR1CYP3A4ESR2
SCHEMBL21547591 0.78 LMNA (0.41) ELANEALDH1A1CNR2KDM4ELMNA
SCHEMBL21547586 0.77 ELANE (0.34) ELANEALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL10605015 0.77 KLF10 (0.46) ALDH1A1ESR1CYP3A4ESR2NR3C2
SCHEMBL21547575 0.75 ACHE (0.35) ALDH1A1CYP3A4KDM4EMEN1KMT2A
SCHEMBL31166663 0.73 KLF10 (0.54) ELANEALDH1A1ESR1CYP3A4ESR2
SCHEMBL31166661 0.73 KLF10 (0.54) ELANEALDH1A1ESR1CYP3A4ESR2
SCHEMBL14999407 0.72 CYP3A4 (0.37) ALDH1A1ESR1CYP3A4ESR2NR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616513-B1 CATALYSTS AND METHODS FOR POLYMER SYNTHESIS SAUDI ARAMCO TECH CO (SA) 2019-11-06 EP disclosed