SCHEMBL21549384

SCHEMBL21549384

CC[C@@H](Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)NC(=O)OC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 3/20 0.49
▸ PPARA Q07869 2/20 0.49
▸ ATM Q13315 1/20 0.49
▸ CTSS P25774 4/20 0.47
▸ CTSK P43235 4/20 0.47
▸ SYK P43405 1/20 0.44
▸ EPHX2 P34913 2/20 0.42
▸ CYP17A1 P05093 1/20 0.42
▸ APP P05067 2/20 0.41
▸ MME P08473 2/20 0.40
▸ MMP2 P08253 1/20 0.40
▸ MMP3 P08254 1/20 0.40
▸ BCL2 P10415 1/20 0.40
▸ FFAR2 O15552 1/20 0.40
▸ PTPRB P23467 1/20 0.40
▸ ACE P12821 1/20 0.40
▸ CPA1 P15085 1/20 0.40
▸ ACE2 Q9BYF1 1/20 0.40
▸ TRPV1 Q8NER1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21549320 0.89 MMP2 (0.46) PPARGPPARAATMCTSSCTSK
SCHEMBL1595057 0.86 ATM (0.52) PPARGPPARAATMCTSSCTSK
SCHEMBL1595060 0.86 ATM (0.52) PPARGPPARAATMCTSSCTSK
SCHEMBL16945133 0.86 CTSS (0.62) PPARGPPARAATMCTSSCTSK
SCHEMBL5757257 0.85 ATM (0.51) PPARGPPARAATMCTSSCTSK
SCHEMBL1519752 0.84 FFAR2 (0.54) PPARGPPARAATMCTSSCTSK
SCHEMBL4659427 0.84 ATM (0.50) PPARGPPARAATMCTSSCTSK
SCHEMBL14430204 0.84 ATM (0.50) PPARGPPARAATMCTSSCTSK
SCHEMBL29163526 0.84 FFAR2 (0.54) PPARGPPARAATMCTSSCTSK
SCHEMBL13970938 0.83 PPARG (0.49) PPARGPPARAATMCTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11384060-B2 Amide compounds and use thereof ALPHALA CO., LTD. (TW) 2022-07-12 — — US disclosed
US-20190337915-A1 AMIDE COMPOUNDS AND USE THEREOF ALPHALA CO., LTD. (TW) 2019-11-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190337915-A1 AMIDE COMPOUNDS AND USE THEREOF GLP1R, IAPP, GPR119 PPARG 93/4885PPARA 161/4885ATM 2352/4885
US-11384060-B2 Amide compounds and use thereof GLP1R, IAPP, GPR119 PPARG 93/4885PPARA 161/4885ATM 2352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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