Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 3/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18744798 | 0.81 | HRH4 (0.40) | KDM4EALDH1A1HSD17B10GRIN2DGRIN3B | |
| SCHEMBL27764047 | 0.71 | KDM4E (0.64) | KDM4EALDH1A1HSD17B10KMT2AHPGD | |
| SCHEMBL22408257 | 0.70 | KMT2A (0.33) | KDM4EALDH1A1KMT2AHPGDTDP1 | |
| SCHEMBL22185228 | 0.70 | HRH4 (0.43) | KDM4EALDH1A1HSD17B10GRIN2DGRIN3B | |
| SCHEMBL17505152 | 0.70 | GPR84 (0.37) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL12559602 | 0.68 | CA12 (0.55) | KDM4EHSD17B10GRIN2DGRIN3BGRIN1 | |
| SCHEMBL24876192 | 0.67 | GRIN2D (0.68) | KDM4EALDH1A1HSD17B10GRIN2DGRIN3B | |
| SCHEMBL31236126 | 0.67 | GRIN2D (0.68) | KDM4EALDH1A1HSD17B10GRIN2DGRIN3B | |
| SCHEMBL5455174 | 0.66 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10KMT2ATAAR1 | |
| SCHEMBL12970080 | 0.66 | BRD4 (0.43) | ALDH1A1HSD17B10GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194383-B1 | QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2019-11-06 | — | — | EP | disclosed |