SCHEMBL21551982

SCHEMBL21551982

O=C(NCCCN1CCOCC1)c1ccc(/C=C/c2ccc(Cl)cc2Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.59
HTR1A P08908 1/20 0.59
MAOA P21397 1/20 0.59
MAOB P27338 1/20 0.59
KCNH2 Q12809 1/20 0.59
CD274 Q9NZQ7 1/20 0.59
TSHR P16473 1/20 0.57
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
KLK7 P49862 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.54
KDM4E B2RXH2 1/20 0.54
LMNA P02545 2/20 0.53
GAA P10253 1/20 0.53
EPHX2 P34913 1/20 0.53
MAPK1 P28482 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21552245 0.94 CD274 (0.68) ALDH1A1HTR1AMAOAMAOBKCNH2
SCHEMBL21552083 0.90 ALDH1A1 (0.55) ALDH1A1KMT2AMEN1
SCHEMBL21551981 0.89 LMNA (0.52) ALDH1A1KMT2AMEN1SMN1; SMN2KDM4E
SCHEMBL21551944 0.88 TSHR (0.59) ALDH1A1HTR1AMAOAMAOBKCNH2
SCHEMBL21552169 0.84 ALDH1A1 (0.63) ALDH1A1HTR1AMAOAMAOBKCNH2
Eprobemide SCHEMBL570896 0.83 ALDH1A1 (0.85) ALDH1A1HTR1AMAOAMAOBKCNH2
SCHEMBL21551954 0.82 TSHR (0.69) ALDH1A1MAOAMAOBTSHRKMT2A
SCHEMBL21568402 0.82 ALDH1A1 (0.52) ALDH1A1HTR1AMAOAMAOBKCNH2
Eprobemide SCHEMBL10495496 0.82 ALDH1A1 (0.82) ALDH1A1HTR1AMAOAMAOBKCNH2
SCHEMBL21551985 0.82 CD274 (0.67) ALDH1A1HTR1AMAOAMAOBKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019216810-A1 NEW ANTIFUNGAL COMPOUNDS URBAN CONSTANTIN (SE) 2019-11-14 WO claimed
WO-2019216810-A1 NEW ANTIFUNGAL COMPOUNDS URBAN CONSTANTIN (SE) 2019-11-14 WO disclosed