Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.57 |
| ▸ | CTSS | P25774 | 15/20 | 0.57 |
| ▸ | CTSL | P07711 | 13/20 | 0.57 |
| ▸ | CTSB | P07858 | 9/20 | 0.57 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155735 | 0.84 | CTSK (0.76) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL4954524 | 0.84 | CTSK (0.51) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL4672347 | 0.78 | CTSK (0.52) | CTSKCTSSCTSLCTSB | |
| SCHEMBL2155770 | 0.78 | CTSK (0.84) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL2155425 | 0.77 | CTSK (0.66) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL2438497 | 0.74 | CTSK (0.61) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL2155487 | 0.74 | CTSK (0.76) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL2156332 | 0.74 | CTSK (0.76) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL1587176 | 0.73 | CTSL (1.00) | CTSKCTSSCTSLCTSBCTSF | |
| SCHEMBL2155642 | 0.73 | CTSL (1.00) | CTSKCTSSCTSLCTSBCTSF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973037-B2 | Cathepsin cysteine protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2011-07-05 | — | — | US | disclosed |
| US-20080188529-A1 | N1-(cyanomethyl)-N2-(2,2,2-trifluoro-1-phenylethyl)-L-leucinamide; antiarthritic agent; osteoporosis and other bone loss disorders | MERCK CANADA INC. (CA) | 2008-08-07 | — | — | US | disclosed |
| US-20030232863-A1 | Such as N1-(1-cyanocyclopropyl)-4-fluoro-N2-((1S)-2,2,2-trifluoro-1-(4' -(methylsulfonyl)-1,1'-biphenyl-4-yl) ethyl)-L-leucinamide; for treating osteoporosis and other bone loss disorders | BAYLY CHRISTOPHER I (CA) | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232863-A1 | Such as N1-(1-cyanocyclopropyl)-4-fluoro-N2-((1S)-2,2,2-trifluoro-1-(4' -(methylsulfonyl)-1,1'-biphenyl-4-yl) ethyl)-L-leucinamide; for treating osteoporosis and other bone loss disorders | CTSE, CTSB, CTSS | CTSK 4/4885CTSS 3/4885CTSL 7/4885 |
| US-20080188529-A1 | N1-(cyanomethyl)-N2-(2,2,2-trifluoro-1-phenylethyl)-L-leucinamide; antiarthritic agent; osteoporosis and other bone loss disorders | CTSE, CTSL, CTSK | CTSK 3/4885CTSS 6/4885CTSL 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.