Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.62 |
| ▸ | PDE5A | O76074 | 2/20 | 0.62 |
| ▸ | USP1 | O94782 | 13/20 | 0.55 |
| ▸ | WDR48 | Q8TAF3 | 13/20 | 0.55 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4864646 | 0.83 | PDE5A (0.67) | PDE5AUSP1WDR48USP2CYP1A2 | |
| SCHEMBL20399159 | 0.83 | PIP4K2C (0.55) | APPPDE5AUSP1WDR48ACP1 | |
| SCHEMBL21567245 | 0.83 | YTHDC1 (0.47) | APPPDE5AUSP1WDR48ACP1 | |
| SCHEMBL20400596 | 0.83 | APP (0.56) | APPPDE5AUSP1WDR48USP2 | |
| SCHEMBL12170181 | 0.82 | KCNA5 (0.61) | USP1WDR48 | |
| SCHEMBL20399129 | 0.80 | PDE4A (0.44) | EGFR | |
| SCHEMBL9776789 | 0.80 | APP (0.67) | APPPDE5AUSP2CYP1A2CYP3A4 | |
| SCHEMBL21567280 | 0.79 | BCHE (0.66) | APPUSP1WDR48ACP1ALDH1A1 | |
| SCHEMBL30092930 | 0.79 | BCHE (0.66) | APPUSP1WDR48ACP1ALDH1A1 | |
| SCHEMBL3638414 | 0.79 | APP (0.74) | APPPDE5AUSP1WDR48ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348460-A1 | ANTI-WOLBACHIA PYRIDO[2,3-d]PYRIMIDINECOMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2023-11-02 | — | — | US | disclosed |
| US-20190345157-A1 | COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348460-A1 | ANTI-WOLBACHIA PYRIDO[2,3-d]PYRIMIDINECOMPOUNDS | PWWP2B, WARS1, PNPO | APP 3897/4885PDE5A 2823/4885USP1 3724/4885 |
| US-20190345157-A1 | COMPOUNDS | ABCB11, LTC4S, AQP1 | APP 2829/4885PDE5A 819/4885USP1 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.