Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.39 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28860671 | 0.89 | SLC37A4 (0.51) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL15782878 | 0.85 | TRPM4 (0.47) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7107682 | 0.83 | KAT8 (0.51) | HPGDALDH1A1KDM4EHSD17B10SLC37A4 | |
| SCHEMBL10684176 | 0.83 | KAT8 (0.51) | HPGDALDH1A1KDM4EHSD17B10SLC37A4 | |
| SCHEMBL22042250 | 0.82 | NCEH1 (0.43) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10976271 | 0.82 | HPGD (0.50) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30689889 | 0.82 | HPGD (0.50) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11024895 | 0.80 | NCEH1 (0.45) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6545326 | 0.80 | HPGD (0.47) | NCEH1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19841040 | 0.79 | ALDH1A1 (0.43) | ALDH1A1KDM4EPRKCISLC37A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | NCEH1 3000/4885HPGD 3373/4885ALDH1A1 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.