Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21076020 | 0.81 | PPARG (0.38) | IDO1TAAR1PPARGPPARANPC1 | |
| SCHEMBL21573071 | 0.80 | HRH3 (0.37) | TAAR1PPARGPPARANPC1RAB9A | |
| SCHEMBL21075947 | 0.77 | TAAR1 (0.45) | IDO1TAAR1PPARGPPARAORAI1 | |
| SCHEMBL18856419 | 0.73 | TP53 (0.35) | — | |
| SCHEMBL7435082 | 0.73 | TAAR1 (0.46) | IDO1TAAR1NPC1RAB9AALDH1A1 | |
| SCHEMBL21538871 | 0.67 | HTR2A (0.55) | IDO1TAAR1MAOB | |
| SCHEMBL24202494 | 0.67 | CPA1 (0.41) | TAAR1PPARGPPARA | |
| SCHEMBL31435841 | 0.66 | HSD11B1 (0.50) | IDO1TAAR1PPARGPPARA | |
| SCHEMBL31435844 | 0.66 | HSD11B1 (0.50) | IDO1TAAR1PPARGPPARA | |
| SCHEMBL16868329 | 0.66 | ALDH1A1 (0.47) | IDO1TAAR1PPARGPPARANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |