Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489952 | 0.75 | GPR3 (0.53) | HTTKMT2AKDM4ESMN1; SMN2POLB | |
| SCHEMBL18856329 | 0.75 | PLA2G2A (0.48) | HTTMEN1KMT2AKDM4EPLA2G2A | |
| SCHEMBL28579416 | 0.74 | CYP1A2 (0.50) | HTTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL9287333 | 0.74 | NPSR1 (0.53) | PLA2G2ASMN1; SMN2TLR8ALDH1A1 | |
| SCHEMBL27999098 | 0.74 | GPR3 (0.52) | HTTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL28158605 | 0.74 | RORC (0.45) | KDM4EPLA2G2ATLR8ALDH1A1ADRA2A | |
| SCHEMBL12277345 | 0.73 | KMT2A (0.46) | MEN1KMT2AKDM4EPLA2G2ASMN1; SMN2 | |
| SCHEMBL28949590 | 0.73 | RORC (0.49) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL21574677 | 0.72 | PKM (0.45) | MEN1KMT2AKDM4EPLA2G2ALMNA | |
| SCHEMBL427733 | 0.71 | GPR3 (0.57) | HTTMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |