Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21574741 | 0.89 | KDM1A (0.44) | PKMKDM4EALDH1A1RORCCYP3A4 | |
| SCHEMBL18856329 | 0.80 | PLA2G2A (0.48) | KDM4EALDH1A1RORCCYP3A4CYP2C19 | |
| SCHEMBL28158605 | 0.79 | RORC (0.45) | KDM4EALDH1A1RORCCYP3A4CYP2C19 | |
| SCHEMBL21574658 | 0.77 | PKM (0.58) | PKMKDM4EALDH1A1L3MBTL1RORC | |
| SCHEMBL21004377 | 0.74 | PKM (0.45) | PKMKDM4EALDH1A1L3MBTL1MAOA | |
| SCHEMBL21574579 | 0.74 | TLR8 (0.41) | PKMKDM4EALDH1A1RORCMAOA | |
| SCHEMBL21574740 | 0.72 | HTT (0.51) | KDM4EALDH1A1LMNAPLA2G2AMAPT | |
| SCHEMBL21939660 | 0.71 | CYP1A2 (0.46) | PKMKDM4EALDH1A1L3MBTL1MAOA | |
| SCHEMBL15119526 | 0.70 | KDM4E (0.49) | PKMKDM4EALDH1A1MAOALMNA | |
| SCHEMBL18856332 | 0.70 | RORC (0.43) | ALDH1A1L3MBTL1RORCCYP2C19PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |