Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19304334 | 0.81 | P4HA1 (0.50) | MAPTL3MBTL1HCAR3HCAR2HPGD | |
| SCHEMBL10066762 | 0.81 | MAPT (0.44) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL17682295 | 0.78 | MAPT (0.42) | MAPTSMN1; SMN2L3MBTL1HRH3KDM4E | |
| SCHEMBL21316613 | 0.78 | MAPT (0.42) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL28188709 | 0.77 | MAPT (0.41) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL28829391 | 0.75 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL15630423 | 0.75 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL28006758 | 0.75 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL27931896 | 0.75 | MAPT (0.50) | MAPTSMN1; SMN2L3MBTL1HRH3KDM4E | |
| SCHEMBL5327128 | 0.74 | MAPT (0.44) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |