Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NNMT | P40261 | 3/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10066762 | 0.85 | MAPT (0.44) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL27536580 | 0.83 | KCNJ1 (0.44) | MAPTSMN1; SMN2L3MBTL1HCAR3RAB9A | |
| SCHEMBL17682295 | 0.82 | MAPT (0.42) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL16853368 | 0.81 | RXFP1 (0.41) | SMN1; SMN2HCAR3NPC1NNMTGABRP | |
| SCHEMBL6456069 | 0.79 | GABRP (0.57) | MAPTL3MBTL1HCAR3HPGDGABRP | |
| SCHEMBL5234177 | 0.79 | NNMT (0.57) | SMN1; SMN2L3MBTL1KDM4ENNMTGABRA5 | |
| SCHEMBL31906275 | 0.79 | GABRP (0.57) | MAPTL3MBTL1HCAR3HPGDGABRP | |
| SCHEMBL15630423 | 0.79 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL28829391 | 0.79 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 | |
| SCHEMBL28006758 | 0.79 | MAPT (0.40) | MAPTSMN1; SMN2L3MBTL1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399976-B2 | Dihydropyrrolopyridine inhibitors of ROR-gamma | VITAE PHARMACEUTICALS, LLC (US) | 2019-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399976-B2 | Dihydropyrrolopyridine inhibitors of ROR-gamma | RORC, RORB, RORA | MAPT 3002/4885SMN1; SMN2 3537/4885L3MBTL1 4755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.