Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | HTR1D | P28221 | 2/20 | 0.31 |
| ▸ | HTR1B | P28222 | 2/20 | 0.31 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.30 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580842 | 0.87 | ADORA1 (0.43) | CXCR2HSD11B1ADORA1 | |
| SCHEMBL31604507 | 0.71 | CXCR2 (0.41) | CXCR2HSD11B1CXCR1DRD2DRD1 | |
| SCHEMBL23700639 | 0.68 | KDM4E (0.42) | HSD11B1ADORA1 | |
| SCHEMBL31604514 | 0.66 | ALDH1A1 (0.40) | CXCR2HSD11B1CXCR1 | |
| SCHEMBL8613925 | 0.64 | TSHR (0.47) | CXCR2HSD11B1ADORA1 | |
| SCHEMBL25085840 | 0.64 | KDM4E (0.47) | — | |
| SCHEMBL12788120 | 0.63 | STS (0.47) | CXCR2HSD11B1ADORA1 | |
| Propionic Acid SCHEMBL6722644 | 0.63 | KMT2A (0.46) | CXCR2HSD11B1CXCR1DRD2DRD1 | |
| SCHEMBL14062440 | 0.62 | DRD2 (0.45) | CXCR2CXCR1DRD2DRD1DRD4 | |
| SCHEMBL8620504 | 0.62 | ALDH1A1 (0.50) | HSD11B1DRD2DRD3HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802549-A1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-04-14 | — | — | EP | disclosed |
| WO-2019228940-A1 | NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-05 | — | — | WO | disclosed |