Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590218 | 0.82 | MAP4K1 (0.63) | MAP4K1MAPK1 | |
| SCHEMBL21592484 | 0.78 | MAP4K1 (0.61) | MAP4K1RETTNIKMAPK1MAP3K11 | |
| SCHEMBL28506193 | 0.77 | TNIK (0.53) | MAP4K1TNIKMAPK1MAP3K11IKBKB | |
| SCHEMBL21592691 | 0.76 | MAP4K1 (0.52) | MAP4K1MAPK1MAP3K11 | |
| SCHEMBL21592694 | 0.73 | MAP4K1 (0.49) | MAP4K1RETTNIKMAPK1MAP3K11 | |
| SCHEMBL18197658 | 0.70 | MAP3K11 (0.73) | MAP4K1TNIKMAPK1MAP3K11IKBKB | |
| SCHEMBL21592476 | 0.69 | MAP4K1 (0.62) | MAP4K1TNIKMAP3K11IKBKBCHUK | |
| SCHEMBL28511435 | 0.69 | SIGMAR1 (0.48) | ABL1INSRFLT3IGF1RKCNH2 | |
| SCHEMBL28906256 | 0.68 | MAP4K1 (0.63) | MAP4K1MAPK1 | |
| SCHEMBL28510087 | 0.68 | MAP3K11 (0.55) | TNIKMAPK1MAP3K11IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |