Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593837 | 0.80 | MAPT (0.47) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30486440 | 0.79 | THRB (0.47) | THRBGPR174GFERMAPTTP53 | |
| SCHEMBL21593842 | 0.79 | ALDH1A1 (0.48) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30009870 | 0.77 | MAPT (0.55) | THRBGPR174GFERMAPTTP53 | |
| SCHEMBL9983954 | 0.74 | GFER (0.63) | THRBGPR174GFERMAPTTP53 | |
| SCHEMBL24490258 | 0.71 | NPC1 (0.48) | TP53SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13419464 | 0.71 | TP53 (0.47) | GFERMAPTTP53LMNANR1I2 | |
| SCHEMBL13419745 | 0.70 | GFER (0.57) | GFERMAPTTP53LMNAALDH1A1 | |
| SCHEMBL9984458 | 0.69 | GPR174 (0.52) | THRBGPR174GFERMAPTTP53 | |
| SCHEMBL12436729 | 0.68 | ALDH1A1 (0.45) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177485-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD. (CN) | 2022-06-09 | — | — | US | disclosed |
| EP-3808751-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Marine Biomedical Research Institute Of Qingdao Co., Ltd. (CN) | 2021-04-21 | — | — | EP | disclosed |
| WO-2019238046-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 青岛海洋生物医药研究院股份有限公司 | 2019-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177485-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | WEE1, WASF2, WEE2 | THRB 3320/4885GPR174 1459/4885GFER 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.