Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213288 | 0.82 | ALDH1A1 (0.50) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL21596383 | 0.81 | GAA (0.62) | MAPTGAAADRA2CKDM4EKMT2A | |
| SCHEMBL574469 | 0.78 | LGMN (0.50) | MAPTGAAKDM4EALDH1A1KMT2A | |
| SCHEMBL28780195 | 0.78 | MAPT (0.48) | MAPTGAAADRA2CKDM4EPTK2B | |
| SCHEMBL4170677 | 0.75 | MAPT (0.46) | MAPTGAAADRA2CKDM4EPTK2B | |
| SCHEMBL6414948 | 0.74 | MAPT (1.00) | MAPTGAAADRA2CKDM4EPTK2B | |
| SCHEMBL6151538 | 0.74 | MAPT (1.00) | MAPTGAAADRA2CKDM4EPTK2B | |
| SCHEMBL56547 | 0.74 | MAPT (1.00) | MAPTGAAADRA2CKDM4EPTK2B | |
| SCHEMBL591377 | 0.73 | ADRA2C (0.56) | MAPTGAAADRA2CKDM4EPTK2B | |
| SCHEMBL18230083 | 0.73 | ALDH1A1 (0.44) | MAPTGAAADRA2CKDM4EPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987267-B2 | 2-substituted-8-alkyl-7-OXO-7,8-dihydropyrido[2,3-D]pyrimidine-6-carbonitriles and uses thereof in treating proliferative disorders | Temple University—Of the Commonwealth System of Higher Education (US) | 2015-03-24 | — | — | US | claimed |
| EP-2600719-B1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | UNIV TEMPLE (US) | 2014-10-08 | — | — | EP | claimed |
| EP-2600719-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | Temple University - Of The Commonwealth System of Higher Education (US) | 2013-06-12 | — | — | EP | claimed |
| US-20130131058-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2013-05-23 | — | — | US | claimed |
| WO-2012018540-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-02-09 | — | — | WO | claimed |
| US-8987267-B2 | 2-substituted-8-alkyl-7-OXO-7,8-dihydropyrido[2,3-D]pyrimidine-6-carbonitriles and uses thereof in treating proliferative disorders | Temple University—Of the Commonwealth System of Higher Education (US) | 2015-03-24 | — | — | US | disclosed |
| EP-2600719-B1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | UNIV TEMPLE (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-2600719-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | Temple University - Of The Commonwealth System of Higher Education (US) | 2013-06-12 | — | — | EP | disclosed |
| US-20130131058-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2013-05-23 | — | — | US | disclosed |
| WO-2012018540-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131058-A1 | 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF | CDK7, CDK2, CDK8 | MAPT 4742/4885GAA 2679/4885ADRA2C 2708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.