Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 9/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596476 | 0.96 | OPRK1 (0.40) | OPRK1NPSR1POLBTSHRHSD17B10 | |
| SCHEMBL28533997 | 0.85 | ALDH1A1 (0.46) | OPRK1HSD17B10TP53RXFP1MAPT | |
| SCHEMBL28522607 | 0.85 | ALDH1A1 (0.46) | TSHRHSD17B10TP53MAPK1MAPT | |
| SCHEMBL9383978 | 0.82 | CASP1 (0.47) | TSHRGAACASP1KDM4E | |
| SCHEMBL2782609 | 0.82 | OPRK1 (0.48) | OPRK1NPSR1POLBTSHRHSD17B10 | |
| SCHEMBL733159 | 0.79 | OPRK1 (0.49) | OPRK1 | |
| SCHEMBL1505507 | 0.79 | OPRK1 (0.46) | OPRK1TSHRGAAKDM4E | |
| SCHEMBL3695889 | 0.73 | CYP1A2 (0.44) | OPRK1NPSR1POLBTSHRHSD17B10 | |
| SCHEMBL2436257 | 0.70 | KDM4E (0.48) | TSHRHSD17B10MAPK1GAAMAPT | |
| SCHEMBL3583952 | 0.70 | OPRK1 (0.49) | OPRK1NPSR1POLBTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810585-A1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS | Bayer Aktiengesellschaft (DE) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243243-A1 | PROCESS FOR PREPARING TRICYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2019-12-26 | — | — | WO | disclosed |