Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879172 | 0.88 | ALDH1A1 (0.58) | ALDH1A1MAOBS1PR1CYP1A1CYP1B1 | |
| SCHEMBL1124419 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MAOBS1PR1MAPTMEN1 | |
| SCHEMBL4529316 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MAOBS1PR1ROCK2ROCK1 | |
| SCHEMBL2160315 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MAOBS1PR1CYP1A1CYP1B1 | |
| SCHEMBL4529312 | 0.84 | ALDH1A1 (0.52) | ALDH1A1MAOBS1PR1ROCK2ROCK1 | |
| SCHEMBL12744692 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAOBS1PR1ROCK2ROCK1 | |
| SCHEMBL2654870 | 0.81 | PTPN1 (0.55) | ALDH1A1MAOBMAPTPTPN1 | |
| SCHEMBL4059477 | 0.81 | ALDH1A1 (0.67) | ALDH1A1MAOBCYP1A1CYP1B1ERN1 | |
| SCHEMBL2352641 | 0.79 | ALDH1A1 (0.65) | ALDH1A1MAOBCYP1A1CYP1B1ROCK2 | |
| SCHEMBL5654410 | 0.78 | ALDH1A1 (0.63) | ALDH1A1MAOBS1PR1CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254886-B1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-05-25 | — | — | EP | disclosed |
| EP-2376492-B1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-08 | — | — | EP | disclosed |
| US-8981092-B2 | Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-17 | — | — | US | disclosed |
| US-8513241-B2 | 3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-08-20 | — | — | US | disclosed |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-05-30 | — | — | US | disclosed |
| US-8394802-B2 | 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-03-12 | — | — | US | disclosed |
| US-20120232085-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-09-13 | — | — | US | disclosed |
| US-8207165-B2 | 3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-26 | — | — | US | disclosed |
| EP-2376492-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-19 | — | — | EP | disclosed |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2011-10-13 | — | — | US | disclosed |
| US-20110183971-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-07-28 | — | — | US | disclosed |
| EP-2254886-A2 | 3,4-DIHYDRO-2H-PYRAZINOÝ1,2-A¨INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Nerviano Medical Sciences S.r.l. (IT) | 2010-12-01 | — | — | EP | disclosed |
| WO-2010031816-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-25 | — | — | WO | disclosed |
| WO-2009118411-A2 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-10-01 | — | — | WO | disclosed |
| WO-2003051877-A1 | 2-SUBSTITUTED PYRROLO[2.1-A]ISOQUINOLINES AGAINST CANCER | BAYER CORPORATION (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183971-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MAP3K1, PDPK1, MAP3K15 | ALDH1A1 2399/4885MAOB 1472/4885S1PR1 1843/4885 |
| US-20120232085-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MAP3K1, PDPK1, MAP3K15 | ALDH1A1 2399/4885MAOB 1472/4885S1PR1 1843/4885 |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | PDK1, PDPK1, CDK3 | ALDH1A1 1974/4885MAOB 4038/4885S1PR1 2015/4885 |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | MAP3K15, MAP3K1, MAP3K3 | ALDH1A1 2930/4885MAOB 3985/4885S1PR1 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.