Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529312 | 0.89 | ALDH1A1 (0.52) | ALDH1A1MAOBS1PR1ROCK2ROCK1 | |
| SCHEMBL12744692 | 0.88 | ALDH1A1 (0.51) | ALDH1A1MAOBS1PR1ROCK2ROCK1 | |
| SCHEMBL1124419 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MAOBPDE3BPDE3AP2RY12 | |
| SCHEMBL5879172 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MAOBPDE3BPDE3AP2RY12 | |
| SCHEMBL12371619 | 0.85 | ALDH1A1 (0.58) | ALDH1A1MAOBROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL2160313 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MAOBS1PR1ROCK2ROCK1 | |
| SCHEMBL12238250 | 0.83 | PDE3B (0.52) | PDE3BPDE3AP2RY12SMN1; SMN2PDK2 | |
| SCHEMBL2554393 | 0.83 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTHDAC8HPGD | |
| SCHEMBL20122046 | 0.83 | MAPT (0.48) | ALDH1A1PDE3BPDE3AP2RY12SMN1; SMN2 | |
| SCHEMBL14586326 | 0.83 | LMNA (0.49) | ALDH1A1PDE3BPDE3AP2RY12SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762008-A1 | HYBRID MU OPIOID RECEPTOR AND NEUROPEPTIDE FF RECEPTOR BINDING MOLECULES, THEIR METHODS OF PREPARATION AND APPLICATIONS IN THERAPEUTIC TREATMENT | Centre National de la Recherche Scientifique (FR) | 2021-01-13 | — | — | EP | disclosed |
| US-20210002231-A1 | HYBRID MU OPIOID RECEPTOR AND NEUROPEPTIDE FF RECEPTOR BINDING MOLECULES, THEIR METHODS OF PREPARATION AND APPLICATIONS IN THERAPEUTIC TREATMENT | UNIVERSITÉ DE STRASBOURG (FR) | 2021-01-07 | — | — | US | disclosed |
| WO-2019170919-A1 | HYBRID MU OPIOID RECEPTOR AND NEUROPEPTIDE FF RECEPTOR BINDING MOLECULES, THEIR METHODS OF PREPARATION AND APPLICATIONS IN THERAPEUTIC TREATMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-12 | — | — | WO | disclosed |
| US-7498460-B2 | Isophthalic acid derivatives | BAYER HEALTHCARE AG (DE) | 2009-03-03 | — | — | US | disclosed |
| US-7091247-B2 | Biphenyl compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-08-15 | — | — | US | disclosed |
| US-20060154912-A1 | Isophtalic acid derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-07-13 | — | — | US | disclosed |
| US-20040106792-A1 | Biphenyl compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | US | disclosed |
| EP-1295867-A1 | BIPHENYL COMPOUND | Takeda Chemical Industries, Ltd. (JP) | 2003-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106792-A1 | Biphenyl compound | GPR4, GPR139, GPR142 | ALDH1A1 1307/4885MAOB 3511/4885PDE3B 2890/4885 |
| US-20060154912-A1 | Isophtalic acid derivatives | VHL, FABP3, CPT1A | ALDH1A1 60/4885MAOB 1051/4885PDE3B 2040/4885 |
| US-20210002231-A1 | HYBRID MU OPIOID RECEPTOR AND NEUROPEPTIDE FF RECEPTOR BINDING MOLECULES, THEIR METHODS OF PREPARATION AND APPLICATIONS IN THERAPEUTIC TREATMENT | OPRL1, OPRM1, NPFFR1 | ALDH1A1 3967/4885MAOB 805/4885PDE3B 3155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.