Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | TPO | P07202 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563483 | 1.00 | MPO (0.46) | MPOTPOCYP3A4GRM5NOS3 | |
| SCHEMBL19119928 | 0.81 | GRM5 (0.46) | MPOTPOCYP3A4GRM5MTOR | |
| SCHEMBL15638519 | 0.78 | NOS3 (0.39) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL28076029 | 0.77 | GRM5 (0.46) | MPOTPOCYP3A4GRM5MTOR | |
| SCHEMBL2643353 | 0.77 | GRM5 (0.46) | MPOTPOCYP3A4GRM5MTOR | |
| SCHEMBL3156955 | 0.77 | GRM5 (0.46) | MPOTPOCYP3A4GRM5MTOR | |
| SCHEMBL38651177 | 0.77 | MAPT (0.63) | GRM5MTORRPTORMLST8MAPT | |
| SCHEMBL8086526 | 0.77 | GRM5 (0.46) | MPOTPOCYP3A4GRM5MTOR | |
| SCHEMBL1907360 | 0.77 | MAPT (0.63) | GRM5MTORRPTORMLST8MAPT | |
| SCHEMBL20242047 | 0.76 | HSP90AA1 (0.43) | MPOMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526098-B1 | NITROGEN-CONTAINING HETEROARYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-07-11 | — | — | EP | claimed |
| US-8470820-B2 | Nitrogen-containing heteroaryl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | claimed |
| US-11548854-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2023-01-10 | — | — | US | disclosed |
| US-11332448-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2022-05-17 | — | — | US | disclosed |
| CN-113243374-B | Heterocyclic compounds as pesticides | 拜耳农作物科学股份公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-113243374-A | Heterocyclic compounds as pesticides | 拜耳农作物科学股份公司 | 2021-08-13 | — | — | CN | disclosed |
| CN-108477173-B | Heterocyclic compounds as pesticides | 拜耳农作物科学股份公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-109476643-B | Pyrazolylaminobenzimidazole derivatives as JAK inhibitors | 伊莱利利公司 | 2021-06-08 | — | — | CN | disclosed |
| EP-3484875-B1 | PYRAZOLYLAMINOBENZIMIDAZOLE DERIVATIVES AS JAK INHIBITORS | LILLY CO ELI (US) | 2021-04-07 | — | — | EP | disclosed |
| US-10961201-B2 | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20210053924-A1 | HETEROCYCLIC COMPOUNDS AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2021-02-25 | — | — | US | disclosed |
| CN-1934100-A | Substituted quinazoline or pyridopyrimidine derivatives | BANYU PHARMA CO LTD (JP) | 2007-03-21 | — | — | CN | disclosed |
| EP-1734040-A1 | SUBSTITUTED QUINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
| CN-1708483-A | Process for preparing pyrazole compounds | BANYU PHARMA CO LTD (JP) | 2005-12-14 | — | — | CN | disclosed |
| US-4881965-A | CONTROLLING WILD OATS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1989-11-21 | — | — | US | disclosed |
| EP-0318602-A1 | Pyrazolesulfonamide derivative, process for its production and herbicide containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-06-07 | — | — | EP | disclosed |
| EP-0207285-A1 | 5-Amino-1-pyridyl-pyrazoles | BAYER AG (DE) | 1987-01-07 | — | — | EP | disclosed |
| CN-86100911-A | The preparation method of pyrazoles sulfone amide derivative and the weedicide that contains this kind derivative | — | 1986-09-24 | — | — | CN | disclosed |
| US-4490376-A | ANTIULCER AND SECRETORY AGENTS | FARMITALIA CARLO ERBA S.P.A (IT) | 1984-12-25 | — | — | US | disclosed |
| US-4482555-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS, AND ANALGESIC | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961201-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | MPO 1163/4885TPO 3273/4885CYP3A4 131/4885 |
| US-11548854-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | MPO 1163/4885TPO 3273/4885CYP3A4 131/4885 |
| US-20210053924-A1 | HETEROCYCLIC COMPOUNDS AS PESTICIDES | DDT, ACHE, PTMS | MPO 1163/4885TPO 3273/4885CYP3A4 131/4885 |
| US-11332448-B2 | Heterocyclic compounds as pesticides | DDT, ACHE, PTMS | MPO 1163/4885TPO 3273/4885CYP3A4 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.