Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21607622 | 0.90 | ALDH1A1 (0.36) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607426 | 0.89 | FAAH (0.41) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607546 | 0.89 | SMAD3 (0.38) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607527 | 0.88 | NR1H2 (0.38) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607458 | 0.86 | FAAH (0.41) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607649 | 0.86 | RORC (0.37) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607802 | 0.82 | ALDH1A1 (0.40) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607819 | 0.80 | FAAH (0.42) | KDM1ASMAD3APAF1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21607433 | 0.77 | FAAH (0.44) | SMAD3APAF1ALDH1A1SMN1; SMN2NR1H2 | |
| SCHEMBL21607427 | 0.77 | FAAH (0.44) | SMAD3APAF1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| CN-112566901-A | Phenyl-substituted pyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-03-26 | — | — | CN | disclosed |
| WO-2019243999-A1 | PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | RORC, RORB, RORA | KDM1A 869/4885SMAD3 1372/4885APAF1 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.