SCHEMBL21609264

SCHEMBL21609264

CCc1ccc(OC)c(SNc2noc3ccc(C)cc23)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HTT P42858 1/20 0.38
MAPT P10636 4/20 0.37
KAT7 O95251 4/20 0.37
KAT6A Q92794 4/20 0.37
TP53 P04637 2/20 0.37
POLB P06746 2/20 0.37
KAT6B Q8WYB5 3/20 0.37
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36
TUBA1A Q71U36 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21609182 0.86 KAT6A (0.41) MAPTKAT7KAT6ATP53POLB
SCHEMBL21609263 0.84 STK17B (0.39) HTTMAPTKAT7KAT6ATP53
SCHEMBL21609142 0.83 CCNC (0.43) MEN1KMT2AMAPTKAT7KAT6A
SCHEMBL21609058 0.82 STK17B (0.36) MAPTKAT7KAT6APOLBKAT6B
SCHEMBL21609008 0.82 BRD4 (0.38) MAPTKAT7KAT6ATP53POLB
SCHEMBL21609254 0.81 KAT6A (0.37) MAPTKAT7KAT6APOLBKAT6B
SCHEMBL21609257 0.80 TUBB4A (0.36) KMT2AHTTMAPTKAT7KAT6A
SCHEMBL21609091 0.79 KAT7 (0.38) MEN1KMT2AMAPTKAT7KAT6A
SCHEMBL21609153 0.79 NPC1 (0.37) MEN1KMT2AHTTMAPTTP53
SCHEMBL21609044 0.79 HTR3A (0.41) KAT7KAT6AKAT6BTUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed