Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161200 | 0.69 | ALDH1A1 (0.35) | LMNATHRBMEN1BLMHBB | |
| SCHEMBL11576700 | 0.69 | — | — | |
| SCHEMBL11287209 | 0.67 | — | — | |
| Trifluoroacetic Acid SCHEMBL7737453 | 0.66 | MEN1 (0.35) | LMNATHRBMEN1BLMHBB | |
| SCHEMBL9510521 | 0.66 | — | — | |
| SCHEMBL11595886 | 0.66 | TSHR (0.37) | LMNA | |
| Trifluoroacetic Acid SCHEMBL2208820 | 0.66 | CA5A (0.50) | LMNATHRBMEN1BLMHBB | |
| SCHEMBL9481179 | 0.65 | — | — | |
| SCHEMBL719462 | 0.64 | ACLY (0.42) | ACLYTHRB | |
| Trifluoroacetic Acid SCHEMBL27696714 | 0.64 | CA5A (0.47) | LMNATHRBMEN1BLMHBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791268-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8642775-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-02-04 | — | — | US | disclosed |
| US-20110184020-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20080262039-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262039-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | TRPV1, TRPV2, TRPV3 | ACLY 2205/4885LMNA 3002/4885THRB 982/4885 |
| US-20110184020-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions | TRPV1, TRPV2, TRPV3 | ACLY 2205/4885LMNA 3002/4885THRB 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.