SCHEMBL21628685

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL6918025	0.89	PLK1 (0.70)	PLK1HDAC6HDAC8ALDH1A1TDP1
	SCHEMBL21628915	0.87	PLK1 (0.60)	PLK1CA1CA2HPGDTSHR
	SCHEMBL21628527	0.86	PLK1 (0.79)	PLK1HPGDTSHRHTTSMN1; SMN2
	SCHEMBL21628407	0.84	PLK1 (0.62)	PLK1CA1CA2HDAC6HDAC8
	SCHEMBL401468	0.84	PLK1 (0.63)	PLK1HDAC6HDAC8ALDH1A1TDP1
	SCHEMBL22192686	0.83	PGR (0.61)	PLK1SMN1; SMN2ALDH1A1HDAC1
	SCHEMBL21628550	0.83	HDAC1 (0.59)	PLK1HDAC6HDAC8HDAC3NCOR2
	SCHEMBL21628734	0.82	OPRM1 (0.54)	HDAC6HDAC8HDAC3HDAC1
	SCHEMBL17946943	0.82	CA1 (0.60)	PLK1CA1CA2SMN1; SMN2ALDH1A1
	SCHEMBL13686078	0.82	ALDH1A1 (0.55)	PLK1HPGDTSHRHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.