Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TYK2 | P29597 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK1 | P23458 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16583943 | 0.89 | GAA (0.59) | MEN1KMT2ALMNATYK2JAK2 | |
| SCHEMBL30739821 | 0.88 | JAK2 (0.69) | MEN1KMT2ALMNATYK2JAK2 | |
| SCHEMBL15205641 | 0.88 | MEN1 (0.55) | MEN1KMT2ALMNATYK2JAK2 | |
| SCHEMBL27778779 | 0.86 | MAPT (0.54) | MEN1KMT2ALMNATYK2HTT | |
| SCHEMBL15597845 | 0.84 | GAA (0.69) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL12334679 | 0.81 | RAB9A (0.56) | MEN1KMT2ATYK2JAK2JAK1 | |
| SCHEMBL16019837 | 0.80 | ITGB1 (0.47) | MEN1KMT2ALMNAHTTCDK1 | |
| SCHEMBL16019871 | 0.80 | ITGB1 (0.45) | MEN1KMT2ALMNAHTTCDK1 | |
| SCHEMBL22871351 | 0.80 | PTGFR (0.52) | MEN1KMT2ALMNATYK2JAK2 | |
| SCHEMBL14887760 | 0.79 | ITGB1 (0.51) | MEN1KMT2ALMNAHTTITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200031801-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031801-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | SDHA, SLC10A1, CYP11B2 | MEN1 391/4885KMT2A 4157/4885LMNA 1413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.